Titanium-based hip stems with drug delivery functionality through additive manufacturing

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dc.contributor.authorBezuidenhout, Martin B.en_ZA
dc.contributor.authorDimitrov, Dimitar M.en_ZA
dc.contributor.authorVan Staden, Anton D.en_ZA
dc.contributor.authorOosthuizen, Gert A.en_ZA
dc.contributor.authorDicks, Leon Milner Theodore, 1961-en_ZA
dc.date.accessioned2016-12-21T06:37:32Z
dc.date.available2016-12-21T06:37:32Z
dc.date.issued2015
dc.descriptionCITATION: Bezuidenhout, M. B. et al. 2015. Titanium-based hip stems with drug delivery functionality through additive manufacturing. BioMed Research International, 2015, Article ID 134093, doi:10.1155/2015/134093.
dc.descriptionThe original publication is available at https://www.hindawi.com/journals/bmri
dc.description.abstractENGLISH ABSTRACT: Postoperative infections are a major concern in patients that receive implants.These infections generally occur in areas with poor blood flow and pathogens do not always respond to antibiotic treatment. With the latest developments in nanotechnology, the incorporation of antibiotics into prosthetic implants may soon become a standard procedure. The success will, however, depend on the ability to control the release of antibiotics at concentrations high enough to prevent the development of antibiotic-resistant strains. Through additive manufacturing, antibiotics can be incorporated into cementless femoral stems to produce prosthetic devices with antimicrobial properties. With the emerging increase in resistance to antibiotics, the incorporation of antimicrobial compounds other than antibiotics, preferably drugs with a broader spectrumof antimicrobial activity, will have to be explored.This review highlights the microorganisms associated with total hip arthroplasty (THA), discusses the advantages and disadvantages of the latest materials used in hip implants, compares different antimicrobial agents that could be incorporated, and addresses novel ideas for future research.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Geen opsomming beskikbaaraf_ZA
dc.description.urihttps://www.hindawi.com/journals/bmri/2015/134093/
dc.description.versionPublisher's version
dc.format.extent12 pages
dc.identifier.citationBezuidenhout, M. B. et al. 2015. Titanium-based hip stems with drug delivery functionality through additive manufacturing. BioMed Research International, 2015, Article ID 134093, doi:10.1155/2015/134093.
dc.identifier.issn2314-6141 (online)
dc.identifier.otherdoi:10.1155/2015/134093
dc.identifier.urihttp://hdl.handle.net/10019.1/100002
dc.language.isoen_ZAen_ZA
dc.publisherHindawi
dc.rights.holderAuthors retain copyright
dc.subjectPostoperative infectionsen_ZA
dc.subjectProsthesisen_ZA
dc.subjectTitanium forgingsen_ZA
dc.subjectHip arthroplastyen_ZA
dc.subjectTitaniumen_ZA
dc.subjectImplants, Artificialen_ZA
dc.titleTitanium-based hip stems with drug delivery functionality through additive manufacturingen_ZA
dc.typeArticleen_ZA
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