Raised ICP in a child with cryptococcal meningitis: CT evidence of a distal CSF block

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dc.contributor.authorSchoeman J.F.
dc.contributor.authorHoney E.M.
dc.contributor.authorLoock D.B.
dc.date.accessioned2011-05-15T16:16:03Z
dc.date.available2011-05-15T16:16:03Z
dc.date.issued1996
dc.description.abstractRaised intracranial pressure (ICP) often complicates the course of cryptococcal meningitis. The pathogenesis of the severely raised cerebrospinal fluid (CSF) pressure commonly associated with this condition is largely unexplained, because the majority of patients have normal cranial computed tomographic (CT) findings when diagnosed. We report a case of cryptococcal meningitis in a child who had severely raised CSF pressure on admission, and in whom repeated CT scanning showed progressive enlargement of the subarachnoid space and ventricular system during the course of treatment. The normalization of these spaces after ventriculoperitoneal (VP) shunting suggests a distal CSF block as the cause of the raised ICP in this patient. The CSF pressure was monitored and treatment with oral acetazolamide and furosemide resulted in a definite, but slow and incomplete lowering of ICP. Intrathecal therapy with hyaluronidase had no beneficial effect on either ICP or the degree of visual loss.
dc.description.versionArticle
dc.identifier.citationChild's Nervous System
dc.identifier.citation12
dc.identifier.citation9
dc.identifier.issn02567040
dc.identifier.urihttp://hdl.handle.net/10019.1/13606
dc.subjectacetazolamide
dc.subjectamphotericin B
dc.subjectfluconazole
dc.subjectfurosemide
dc.subjecthyaluronidase
dc.subjectarticle
dc.subjectbrain ventricle peritoneum shunt
dc.subjectcase report
dc.subjectcomputer assisted tomography
dc.subjectfemale
dc.subjectfungal meningitis
dc.subjecthuman
dc.subjectintracranial hypertension
dc.subjectintrathecal drug administration
dc.subjectintravenous drug administration
dc.subjectoral drug administration
dc.subjectpriority journal
dc.subjectschool child
dc.subjectCerebrospinal Fluid
dc.subjectChild
dc.subjectFemale
dc.subjectHumans
dc.subjectHydrocephalus
dc.subjectMeningitis, Cryptococcal
dc.subjectMonitoring, Physiologic
dc.subjectPseudotumor Cerebri
dc.subjectSubarachnoid Space
dc.subjectTomography, X-Ray Computed
dc.subjectVentriculoperitoneal Shunt
dc.titleRaised ICP in a child with cryptococcal meningitis: CT evidence of a distal CSF block
dc.typeArticle
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