Detectable HIV-1 in semen in individuals with very low blood viral loads

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dc.contributor.authorKariuki, Samuel Mundiaen_ZA
dc.contributor.authorSelhorst, Philippeen_ZA
dc.contributor.authorNorman, Jenniferen_ZA
dc.contributor.authorCohen, Karenen_ZA
dc.contributor.authorRebe, Kevinen_ZA
dc.contributor.authorWilliamson, Carolynen_ZA
dc.contributor.authorDorfman, Jeffrey Ren_ZA
dc.date.accessioned2020-03-09T06:22:44Z
dc.date.available2020-03-09T06:22:44Z
dc.date.issued2020-03-05
dc.date.updated2020-03-08T04:22:00Z
dc.descriptionCITATION: Kariuki, S. M., et al. 2020. Detectable HIV-1 in semen in individuals with very low blood viral loads. Virology Journal, 17:29, doi:10.1186/s12985-020-01300-6.
dc.descriptionThe original publication is available at https://virologyj.biomedcentral.com
dc.description.abstractBackground: Several reports indicate that a portion (5–10%) of men living with HIV-1 intermittently shed HIV-1 RNA into seminal plasma while on long term effective antiretroviral therapy (ART). This is highly suggestive of an HIV-1 reservoir in the male genital tract. However, the status of this reservoir in men living with HIV-1 who are not under treatment is underexplored and has implications for understanding the origins and evolution of the reservoir. Finding: Forty-three HIV-1 positive, antiretroviral therapy naïve study participants attending a men’s health clinic were studied. Semen viral loads and blood viral loads were generally correlated, with semen viral loads generally detected in individuals with blood viral loads > 10,000 cp/ml. However, we found 1 individual with undetectable viral loads (<20cp/ml) and 2 individuals with very low blood viral load (97 and 333cp/ml), but with detectable HIV-1 in semen (485–1157 copies/ semen sample). Blood viral loads in the first individual were undetectable when tested three times over the prior 5 years. Conclusions: Semen HIV-1 viral loads are usually related to blood viral loads, as we confirm. Nonetheless, this was not true in a substantial minority of individuals suggesting unexpectedly high levels of replication in the male genital tract in a few individuals, despite otherwise effective immune control. This may reflect establishment of a local reservoir of HIV-1 populations.
dc.description.urihttps://virologyj.biomedcentral.com/articles/10.1186/s12985-020-01300-6
dc.description.versionPublisher's version
dc.format.extent5 pagesen_ZA
dc.identifier.citationKariuki, S. M., et al. 2020. Detectable HIV-1 in semen in individuals with very low blood viral loads. Virology Journal, 17:29, doi:10.1186/s12985-020-01300-6
dc.identifier.issn1743-422X (online)
dc.identifier.otherdoi:10.1186/s12985-020-01300-6
dc.identifier.urihttp://hdl.handle.net/10019.1/107593
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Centralen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectHIV positive peopleen_ZA
dc.subjectSemenen_ZA
dc.subjectAIDS (Diseases)en_ZA
dc.subjectViral loaden_ZA
dc.titleDetectable HIV-1 in semen in individuals with very low blood viral loadsen_ZA
dc.typeArticleen_ZA
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