Anti-mycobacterium tuberculosis activity of polyherbal medicines used for the treatment of tuberculosis in Eastern Cape, South Africa

Simple item page
dc.contributor.authorFamewo, Elizabeth B.en_ZA
dc.contributor.authorClarke, Anna M.en_ZA
dc.contributor.authorWiid, Ianen_ZA
dc.contributor.authorNgwane, Andileen_ZA
dc.contributor.authorVan Helden, Paulen_ZA
dc.contributor.authorAfolayan, Anthony J.en_ZA
dc.date.accessioned2018-06-25T07:43:33Z
dc.date.available2018-06-25T07:43:33Z
dc.date.issued2017
dc.descriptionCITATION: amewo, E. B., et al. 2017. Anti-mycobacterium tuberculosis activity of polyherbal medicines used for the treatment of tuberculosis in Eastern Cape, South Africa. African Health Sciences, 17(3): 780-789, doi:10.4314/ahs.v17i3.21.
dc.descriptionThe original publication is available at https://www.ajol.info/index.php/ahs/index
dc.description.abstractBackground: The emergence of drug-resistant strains of Mycobacterium tuberculosis has become a global public health problem. Polyherbal medicines offer great hope for developing alternative drugs for the treatment of tuberculosis. Objective: To evaluate the anti-tubercular activity of polyherbal medicines used for the treatment of tuberculosis. Methods: The remedies were screened against Mycobacterium tuberculosis H37Rv using Middlebrook 7H9 media and MGIT BACTEC 960 system. They were liquid preparations from King Williams Town site A (KWTa), King Williams Town site B (KWTb), King Williams Town site C (KWTc), Hogsback first site (HBfs), Hogsback second site (HBss), Hogsback third site (HBts), East London (EL), Alice (AL) and Fort Beaufort (FB). Results: The susceptibility testing revealed that all the remedies contain anti-tubercular activity with KWTa, KWTb, KWTc, HBfs, HBts, AL and FB exhibiting more activity at a concentration below 25 μl/ml. Furthermore, MIC values exhibited inhibitory activity with the most active remedies from KWTa, HBfs and HBts at 1.562 μg/ml. However, isoniazid showed more inhibitory activity against M. tuberculosis at 0.05 μg/ml when compare to the polyherbal remedies. Conclusion: This study has indicated that these remedies could be potential sources of new anti-mycobacterial agents against M. tuberculosis. However, the activity of these preparations and their active principles still require in vivo study in order to assess their future as new anti-tuberculosis agents.en_ZA
dc.description.urihttps://www.ajol.info/index.php/ahs/article/view/161253
dc.description.versionPublishers' Version
dc.format.extent10 pages
dc.identifier.citationFamewo, E. B., et al. 2017. Anti-mycobacterium tuberculosis activity of polyherbal medicines used for the treatment of tuberculosis in Eastern Cape, South Africa. African Health Sciences, 17(3): 780-789, doi:10.4314/ahs.v17i3.21
dc.identifier.issn1729-0503 (online)
dc.identifier.issn1680-6905 (print)
dc.identifier.otherdoi:10.4314/ahs.v17i3.21
dc.identifier.urihttp://hdl.handle.net/10019.1/104088
dc.language.isoen_ZAen_ZA
dc.publisherMakerere University, Faculty of Medicine
dc.rights.holderAuthors retain copyright
dc.subjectMycobacterium tuberculosisen_ZA
dc.subjectTuberculosisen_ZA
dc.titleAnti-mycobacterium tuberculosis activity of polyherbal medicines used for the treatment of tuberculosis in Eastern Cape, South Africaen_ZA
dc.typeArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
famewo_mycobacterium_2017.pdf
Size:
441.89 KB
Format:
Adobe Portable Document Format
Description:
Download article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.95 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Molecular Biology and Human Genetics)