Effect of fibroids on fertility in patients undergoing assisted reproduction: A structured literature review

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dc.contributor.authorBenecke C.
dc.contributor.authorKruger T.F.
dc.contributor.authorSiebert T.I.
dc.contributor.authorVan Der Merwe J.P.
dc.contributor.authorSteyn D.W.
dc.date.accessioned2011-05-15T16:16:29Z
dc.date.available2011-05-15T16:16:29Z
dc.date.issued2005
dc.description.abstractObjective: The aim of this study is to evaluate the current data to understand the impact of intramural leiomyomata on pregnancy outcome in assisted reproduction. Patients and Methods: In this review, articles were found by means of computerized Medline and Cochrane Library search using the keywords uterine myomata, leiomyomata, fibroids, implantation, pregnancy, infertility and in vitro fertilization. Limitations were English, human, 1990-2002. Inclusion criteria were pregnancy data on in vitro fertilization, intramural myomata with no cavitary distortion and control groups without myomas for each patient with a myoma. Results: There was a significant negative impact on implantation rate in the intramural myomata groups versus the control groups, 16.4 vs. 27.7% OR 0.62 (0.48-0.8). The delivery rate per transfer cycle was also significantly lower (myomata vs. control), 31.2 vs. 40.9% OR 0.69 (0.50-0.95). Conclusion: Our study supports the notion that patients with intramural fibroids have a lower implantation rate per cycle. The studies did not shed new light on the size of intramural myomata that could affect the outcome. In previous failed in vitro fertilization cycles, microsurgical removal of myomata must be considered. Copyright © 2005 S. Karger AG.
dc.description.versionReview
dc.identifier.citationGynecologic and Obstetric Investigation
dc.identifier.citation59
dc.identifier.citation4
dc.identifier.issn03787346
dc.identifier.other10.1159/000084513
dc.identifier.urihttp://hdl.handle.net/10019.1/13805
dc.subjectadult
dc.subjectCochrane Library
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectfertility
dc.subjectfertilization in vitro
dc.subjecthuman
dc.subjectimplantation
dc.subjectinfertility
dc.subjectleiomyomatosis
dc.subjectMEDLINE
dc.subjectoutcomes research
dc.subjectpregnancy complication
dc.subjectpriority journal
dc.subjectreproduction
dc.subjectreview
dc.subjectuterus myoma
dc.subjectAdult
dc.subjectEmbryo Implantation
dc.subjectFemale
dc.subjectHumans
dc.subjectInfertility, Female
dc.subjectLeiomyoma
dc.subjectPregnancy
dc.subjectPregnancy Outcome
dc.subjectReproductive Techniques, Assisted
dc.subjectUterine Neoplasms
dc.titleEffect of fibroids on fertility in patients undergoing assisted reproduction: A structured literature review
dc.typeReview
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