c-erbB-2 oncogene product staining in gastric adenocarcinoma. An immunohistochemical study

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dc.contributor.authorFalck V.G.
dc.contributor.authorGullick W.J.
dc.date.accessioned2011-05-15T16:17:07Z
dc.date.available2011-05-15T16:17:07Z
dc.date.issued1989
dc.description.abstractThe c-erbB-2 oncogene has been shown to be amplified in a variety of human adenocarcinomas. Antibodies to the protein product, p185, have been used for immunostaining of paraffin-embedded material, and have demonstrated that high levels of c-erbB-2 protein expression correlate with gene amplification under certain conditions. In studies by others, amplification has been demonstrated in 40 per cent of tubular type adenocarcinomas of the stomach, and an immunohistochemical study on frozen tissue has demonstrated staining in 3 out of 10 cases. Our study, using paraffin-embedded material, demonstrates staining in 19 per cent of 126 cases using a polyclonal antibody. Of the positive cases, 75 per cent were tubular or papillary type (P<0.025), and prominent staining was restricted to this group. Three cases showed well-defined positive areas in keeping with clonal expression of p185. No specific staining of normal or dysplastic epithelium adjacent to the carcinomas was found.
dc.description.versionArticle
dc.identifier.citationJournal of Pathology
dc.identifier.citation159
dc.identifier.citation2
dc.identifier.issn00223417
dc.identifier.urihttp://hdl.handle.net/10019.1/14077
dc.subjectadenocarcinoma
dc.subjectadult
dc.subjectaged
dc.subjectfemale
dc.subjecthistochemistry
dc.subjecthuman
dc.subjecthuman cell
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectoncogene
dc.subjectpriority journal
dc.subjectstaining
dc.subjectstomach carcinoma
dc.subjectAdenocarcinoma
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectFemale
dc.subjectGene Amplification
dc.subjectHuman
dc.subjectMale
dc.subjectMiddle Age
dc.subjectProto-Oncogene Proteins
dc.subjectReceptor, erbB-2
dc.subjectStomach Neoplasms
dc.titlec-erbB-2 oncogene product staining in gastric adenocarcinoma. An immunohistochemical study
dc.typeArticle
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