Symmetry symptoms in obsessive-compulsive disorder : clinical and genetic correlates

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dc.contributor.authorLochner, Christineen_ZA
dc.contributor.authorMcGregor, Nathanielen_ZA
dc.contributor.authorHemmings, Sian M. J.en_ZA
dc.contributor.authorHarvey, Brian H.en_ZA
dc.contributor.authorBreet, Elsieen_ZA
dc.contributor.authorSwanevelder, Sonjaen_ZA
dc.contributor.authorStein, Dan J.en_ZA
dc.date.accessioned2017-10-12T14:11:18Z
dc.date.available2017-10-12T14:11:18Z
dc.date.issued2016
dc.descriptionCITATION: Lochner, C., et al. 2016. Symmetry symptoms in obsessive-compulsive disorder : clinical and genetic correlates. Revista Brasileira de Psiquiatria, 38(1):17–23, doi:10.1590/1516-4446-2014-1619.
dc.description.abstractObjective: In obsessive-compulsive disorder (OCD), symmetry-related symptoms may be important. Although clinical correlates of symmetry-related symptoms have been identified in OCD, few data exist on genetic associations. Animal studies indicate involvement of dopamine in symmetry-related behavior, suggesting this may be relevant to analogous symptoms in OCD. Alterations in dopamine may also reflect environmental influences. However, the association of symmetry-related symptomatology, early adversity, and polymorphisms in dopaminergic genes has not been investigated in OCD. Methods: Clinical information and polymorphisms in key dopaminergic genes were compared between OCD patients with primary symmetry symptoms and those without. Results: OCD patients with primary symmetry symptoms comprised 46.6% (n=210) of the sample (n=451), and were older (p < 0.01), had longer illness duration (p < 0.01), higher OCD severity scores (p = 0.01), and greater comorbidity (p < 0.01) than those without. In Caucasians (n=343), genotype frequency differed significantly between groups for ANKK1 rs1800497, with more OCD patients with symmetry symptoms being homozygous for the A2 (CC) genotype (χ2 = 7.296; p = 0.026). Conclusion: Symmetry symptoms have some distinct clinical features and may represent a marker of severity in OCD. However, clinical associations, in combination with the association found with the ANKK1 rs1800497 A2 variant, suggest that primary symmetry symptoms may represent a distinctive clinical and psychobiological profile.en_ZA
dc.description.urihttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016000100017&lng=en&tlng=en
dc.description.versionPublisher's version
dc.format.extent7 pages
dc.identifier.citationLochner, C., et al. 2016. Symmetry symptoms in obsessive-compulsive disorder : clinical and genetic correlates. Revista Brasileira de Psiquiatria, 38(1):17–23, doi:10.1590/1516-4446-2014-1619
dc.identifier.issn1809-452X (online)
dc.identifier.issn1516-4446 (print)
dc.identifier.otherdoi:10.1590/1516-4446-2014-1619
dc.identifier.urihttp://hdl.handle.net/10019.1/102320
dc.language.isoen_ZAen_ZA
dc.publisherAssociacao Brasileira de Psiquiatria
dc.rights.holderAuthors retain copyright
dc.subjectObsessive-compulsive disorderen_ZA
dc.titleSymmetry symptoms in obsessive-compulsive disorder : clinical and genetic correlatesen_ZA
dc.typeArticleen_ZA
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