Enhanced oxidative stress and other potential biomarkers for retinopathy in type 2 diabetics : beneficial effects of the nutraceutic supplements

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dc.contributor.authorRoig-Revert, Maria J.en_ZA
dc.contributor.authorLleo-Perez, Antonioen_ZA
dc.contributor.authorZanon-Moreno, Vicenteen_ZA
dc.contributor.authorVivar-Llopis, Barbaraen_ZA
dc.contributor.authorMarin-Montiel, Juanen_ZA
dc.contributor.authorDolz-Marco, Rosaen_ZA
dc.contributor.authorAlonso-Munoz, Luisen_ZA
dc.contributor.authorAlbert-Fort, Maraen_ZA
dc.contributor.authorLopez-Galvez, Maria I.en_ZA
dc.contributor.authorGalarreta-Mira, Daviden_ZA
dc.contributor.authorGarcia-Esparza, Maria F.en_ZA
dc.contributor.authorGalbis-Estrada, Carmenen_ZA
dc.contributor.authorMarco-Ramirez, Carlaen_ZA
dc.contributor.authorShoaie-Nia, Kianen_ZA
dc.contributor.authorSanz-Gonzalez, Silvia M.en_ZA
dc.contributor.authorVila-Bou, Vicenteen_ZA
dc.contributor.authorBendala-Tufanisco, Elenaen_ZA
dc.contributor.authorGarcia-Medina, Jose J.en_ZA
dc.contributor.authorNucci, Carloen_ZA
dc.contributor.authorGallego-Pinazo, Robertoen_ZA
dc.contributor.authorArevalo, J. Fernandoen_ZA
dc.contributor.authorPinazo-Duran, Maria D.en_ZA
dc.contributor.authorValencia Study on Diabetic Retinopathy (VSDR)en_ZA
dc.date.accessioned2016-12-21T07:11:56Z
dc.date.available2016-12-21T07:11:56Z
dc.date.issued2015
dc.descriptionCITATION: Roig-Revert, M. J. et al. 2015. Enhanced oxidative stress and other potential biomarkers for retinopathy in type 2 diabetics : beneficial effects of the nutraceutic supplements. BioMed Research International, 2015, Article ID 408180, doi:10.1155/2015/408180.
dc.descriptionThe original publication is available at https://www.hindawi.com/journals/bmri
dc.description.abstractWe have studied the global risk of retinopathy in a Mediterranean population of type 2 diabetes mellitus (T2DM) patients, according to clinical, biochemical, and lifestyle biomarkers. The effects of the oral supplementation containing antioxidants/omega 3 fatty acids (A/ω3) were also evaluated. Suitable participants were distributed into two main groups: (1) T2DMG (with retinopathy (+DR) or without retinopathy (−DR)) and (2) controls (CG). Participants were randomly assigned (+A/ω3) or not (−A/ω3) to the oral supplementation with a daily pill of Nutrof Omega (R) for 18 months. Data collected including demographics, anthropometrics, characteristics/lifestyle, ophthalmic examination (best corrected visual acuity, ocular fundus photographs, and retinal thickness as assessed by optical coherence tomography), and blood parameters (glucose, glycosylated hemoglobin, triglycerides, malondialdehyde, and total antioxidant capacity) were registered, integrated, and statistically processed by the SPSS 15.0 program. Finally, 208 participants (130 diabetics (68 +DR/62 −DR) and 78 controls) completed the follow-up. Blood analyses confirmed that the T2DMG+DR patients had significantly higher oxidative stress , inflammatory , and vascular risk markers than the T2DMG−DR and the CG. Furthermore, the A/ω3 oral supplementation positively changed the baseline parameters, presumptively by inducing metabolic activation and ameliorating the ocular health after 18 months of supplementation.en_ZA
dc.description.urihttps://www.hindawi.com/journals/bmri/2015/408180/
dc.description.versionPublisher's version
dc.format.extent13 pagesen_ZA
dc.identifier.citationRoig-Revert, M. J. et al. 2015. Enhanced oxidative stress and other potential biomarkers for retinopathy in type 2 diabetics : beneficial effects of the nutraceutic supplements. BioMed Research International, 2015, Article ID 408180, doi:10.1155/2015/408180.
dc.identifier.issn2314-6141 (online)
dc.identifier.otherdoi:10.1155/2015/408180
dc.identifier.urihttp://hdl.handle.net/10019.1/100004
dc.language.isoen_ZAen_ZA
dc.publisherHindawien_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectType 2 diabetesen_ZA
dc.subjectBiochemical markersen_ZA
dc.subjectOxidative stressen_ZA
dc.subjectDiabetic retinopathyen_ZA
dc.subjectNeutraceuticals -- Nutritional supplementsen_ZA
dc.titleEnhanced oxidative stress and other potential biomarkers for retinopathy in type 2 diabetics : beneficial effects of the nutraceutic supplementsen_ZA
dc.typeArticleen_ZA
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