Factors affecting pregnancy outcome in a gamete intrafallopian transfer (GIF) programme

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dc.contributor.authorDe Bruijn, J. M.en_ZA
dc.contributor.authorKruger, T. F.en_ZA
dc.contributor.authorVan der Merwe, J. P.en_ZA
dc.contributor.authorStander, F. S. H.en_ZA
dc.contributor.authorLombard, C. J.en_ZA
dc.date.accessioned2011-03-18T14:59:26Z
dc.date.available2011-03-18T14:59:26Z
dc.date.issued2003-07
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.descriptionCITATION: De Bruijn, J. M., et al. 2003. Factors affecting pregnancy outcome in a gamete intrafallopian transfer (GIF) programme. South African Medical Journal, 93(7):532-536.en_ZA
dc.description.abstractObjective. To identify the factors that most significantly affected pregnancy rates in a gamete intrafallopian transfer (GIFT) programme. Methods. A total of 863 GIFT cycles were analysed retrospectively. The variables found to be associated significantly with pregnancy were then used to obtain multivariate analysis using logistical regression. Results. Overall and ongoing pregnancy rates were significantly better in patients ≤ 38 years than in patients > 38 years (37.3% and 28.4% v. 23.7% and 11.0% respectively), and age was positively associated with success after GIFT (odds ratio (OR) 1.87, 95% confidence interval (CI): 1.22 - 2.85). Metaphase I (MI) oocytes were negatively associated with pregnancy (OR 1.54, 95% CI: 0.28 - 1.04). The highest pregnancy rates occurred when 3 metaphase II (MII) oocytes were transferred (39.8%, OR 7.51, 95% CI: 1.74 - 32.42). With regard to sperm morphology, overall pregnancy rates of 25.5% (≤ 4% normal forms) and 37.2% (> 4% normal forms) were obtained. Morphology of > 4% normal forms was positively associated with pregnancy (OR 1.58, 95% CI: 1.04 - 2.42). Conclusion. The results of this study suggest that the most important factors influencing pregnancy rates in a GIFT programme are the woman's age and those factors pertaining to the characteristics of the gametes. Considering the emotional and financial costs it is important to relate this information to all prospective participants in a GIFT programme.
dc.description.versionPublisher’s version
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7832
dc.language.isoen
dc.publisherHealth & Medical Publishing Group
dc.rights.holderSouth African Medical Journal
dc.subjectGametes -- Formationen_ZA
dc.subjectSpermatozoaen_ZA
dc.subjectGamete intrafallopian transfer (GIF)en_ZA
dc.subjectInfertilityen_ZA
dc.subjectFallopian tubes -- Surgeryen_ZA
dc.titleFactors affecting pregnancy outcome in a gamete intrafallopian transfer (GIF) programmeen_ZA
dc.typeArticle
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