Venous bicarbonate and creatine kinase as diagnostic and prognostic tools in the setting of acute traumatic rhabdomyolysis
| dc.contributor.author | Buitendag, J. J. P. | en_ZA |
| dc.contributor.author | Patel, M. Q. | en_ZA |
| dc.contributor.author | Variawa, S. | en_ZA |
| dc.contributor.author | Fichardt, J. | en_ZA |
| dc.contributor.author | Mostert, B. | en_ZA |
| dc.contributor.author | Goliath, A. | en_ZA |
| dc.contributor.author | Clarke, D. L. | en_ZA |
| dc.contributor.author | Oosthuizen, G. V. | en_ZA |
| dc.date.accessioned | 2023-05-10T08:33:08Z | en_ZA |
| dc.date.available | 2023-05-10T08:33:08Z | en_ZA |
| dc.date.issued | 2021-03 | en_ZA |
| dc.description | CITATION: Buitendag, J. J. P. et al. 2021. Venous bicarbonate and creatine kinase as diagnostic and prognostic tools in the setting of acute traumatic rhabdomyolysis. South African Medical Journal, 111(4):333-337, doi:10.7196/SAMJ.2021.v111i4.14915. | en_ZA |
| dc.description | The original publication is available at http://www.samj.org.za | en_ZA |
| dc.description.abstract | Background: Myorenal or crush syndrome often develops following soft-tissue traumatic injury. It is a spectrum of disease that may result in severe renal dysfunction and kidney injury requiring renal replacement therapy. Objectives: To review a large cohort of patients with so-called myorenal or crush syndrome and assess the biochemical markers of venous bicarbonate and creatine kinase as predictors for the development of acute kidney injury (AKI). Methods: All patients with myorenal syndrome who presented to Khayelitsha District Hospital, Cape Town, South Africa (SA), and Ngwelezana Hospital, Empangeni, KwaZulu-Natal, SA, between January and December 2017 were identified and reviewed. Results: A total of 212 patients were included in the study. At both hospitals, 94% of the patients were male. Using the Pearson correlation coefficient, we compared creatinine kinase (CK) against serum creatinine. The mean CK level was 5 311.8 U/L and the mean creatinine level 133.457 μmol/L. The r-value was 0.2533. Although this is a technically positive correlation, the relationship between the variables is weak. Using the Pearson R Calculator, we inserted the r-value to calculate the p-value. The p-value was 0.000208. When comparing venous bicarbonate (HCO3) against creatinine, the mean HCO3 level was 22.296 mmol/L and the mean creatinine level 162.053 μmol/L. The r-value was -0.3468. Although this is a technically negative correlation, the relationship between the variables is weak. Using the Pearson R Calculator, we inserted the r-value to calculate the p-value. The p-value was 0.000013. The inverse ratio shown with HCO3 v. creatinine, although still a weak correlation, is significantly better in predicting an increase in creatinine compared with the weak positive correlation of CK v. creatinine. Conclusions: Although both venous HCO3 and CK showed a weak correlation with creatinine, the former performed significantly better in predicting AKI. In a resource-constrained system, we recommend that HCO3 be measured to assess patients with crush injury and that CK be regarded as a complementary modality. | en_ZA |
| dc.description.uri | http://www.samj.org.za/index.php/samj/article/view/13246 | en_ZA |
| dc.description.version | Publisher's version | en_ZA |
| dc.format.extent | 5 pages | en_ZA |
| dc.identifier.citation | Buitendag, J. J. P. et al. 2021. Venous bicarbonate and creatine kinase as diagnostic and prognostic tools in the setting of acute traumatic rhabdomyolysis. South African Medical Journal, 111(4):333-337, doi:10.7196/SAMJ.2021.v111i4.14915. | en_ZA |
| dc.identifier.issn | 2078-5135 (online) | en_ZA |
| dc.identifier.issn | 0256-9574 (print) | en_ZA |
| dc.identifier.other | doi:10.7196/SAMJ.2021.v111i4.14915 | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/10019.1/126885 | en_ZA |
| dc.language.iso | en_ZA | en_ZA |
| dc.publisher | Health & Medical Publishing Group | en_ZA |
| dc.rights.holder | Authors retain copyright | en_ZA |
| dc.subject | Crush syndrome | en_ZA |
| dc.subject | Biochemical markers | en_ZA |
| dc.subject | Creatine kinase | en_ZA |
| dc.subject | Kidneys -- Diseases | en_ZA |
| dc.title | Venous bicarbonate and creatine kinase as diagnostic and prognostic tools in the setting of acute traumatic rhabdomyolysis | en_ZA |
| dc.type | Article | en_ZA |