Morbidity and mortality up to 5 years post tuberculosis treatment in South Africa : a pilot study

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dc.contributor.authorOsman, Muhammaden_ZA
dc.contributor.authorWelte, Alexen_ZA
dc.contributor.authorDunbar, Roryen_ZA
dc.contributor.authorBrown, Rosemaryen_ZA
dc.contributor.authorHoddinott, Graemeen_ZA
dc.contributor.authorHesseling, Anneke C.en_ZA
dc.contributor.authorMarx, Florian M.en_ZA
dc.date.accessioned2021-10-21T12:55:07Z
dc.date.available2021-10-21T12:55:07Z
dc.date.issued2019
dc.descriptionCITATION: Osman, M., et al. 2019. Morbidity and mortality up to 5 years post tuberculosis treatment in South Africa : a pilot study. International Journal of Infectious Diseases, 85:57-63, doi:10.1016/j.ijid.2019.05.024.
dc.descriptionThe original publication is available at https://www.clinicalkey.com/
dc.description.abstractBackground: A high risk of tuberculosis (TB), chronic lung disease, and mortality have been reported among people with a history of previous TB treatment, but data from high-incidence settings remain limited. The aim of this study was to characterize general morbidity and mortality among adults who had successfully completed TB treatment in the past 5 years in a high-incidence setting in South Africa. Methods: Adults ( 18 years) who had completed treatment for pulmonary TB between 2013 and 2017 were randomly selected from TB treatment registers. Household visits were conducted to locate and interview former TB (FTB) patients, and bacteriological testing for TB was offered. Additional data sources were used to ascertain the vitality status of FTB patients who could not be located. Results: Addresses were located for 200 of the 223 FTB patients sampled and 89 FTB patients were contacted of whom 51 agreed to be interviewed. Approximately half reported persistent respiratory symptoms, such as shortness of breath and wheezing, and repeated lung infections. One (3.6%) of 28 patients who provided a sputum sample had culture-positive TB and another two were currently on re-treatment for TB. Fifteen deaths post treatment were ascertained, resulting in a standardized mortality ratio of 3.8 (95% confidence interval 2.3–6.3) after successful TB treatment relative to the general population. Conclusions: In this high-incidence setting, locating and interviewing FTB patients was challenging. The study findings are consistent with a high rate of respiratory disease, including recurrent TB, and substantially elevated mortality among FTB patients.en_ZA
dc.description.urihttps://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1201971219302310?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1201971219302310%3Fshowall%3Dtrue&referrer=https:%2F%2Fpubmed.ncbi.nlm.nih.gov%2F
dc.description.versionPublisher's version
dc.format.extent7 pagesen_ZA
dc.identifier.citationOsman, M., et al. 2019. Morbidity and mortality up to 5 years post tuberculosis treatment in South Africa : a pilot study. International Journal of Infectious Diseases, 85:57-63, doi:10.1016/j.ijid.2019.05.024
dc.identifier.issn1201-9712 (online)
dc.identifier.otherdoi:10.1016/j.ijid.2019.05.024
dc.identifier.urihttp://hdl.handle.net/10019.1/123277
dc.language.isoen_ZAen_ZA
dc.publisherElsevieren_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectTuberculosis -- Treatmenten_ZA
dc.subjectTuberculosis -- Diseasesen_ZA
dc.subjectTuberculosis -- Mortalityen_ZA
dc.subjectLungs -- Diseases, Obstructiveen_ZA
dc.titleMorbidity and mortality up to 5 years post tuberculosis treatment in South Africa : a pilot studyen_ZA
dc.typeArticleen_ZA
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