Rapid emergence of resistance to antiretroviral treatment after undisclosed prior exposure : a case report

Simple item page
dc.contributor.authorRossouw, Theresa M.en_ZA
dc.contributor.authorVan Dyk, Giselaen_ZA
dc.contributor.authorvan Zyl, Gerten_ZA
dc.date.accessioned2021-02-25T14:33:54Z
dc.date.available2021-02-25T14:33:54Z
dc.date.issued2019
dc.descriptionCITATION: Rossouw, T. M., Van Dyk, G. & Van Zyl, G. 2019. Rapid emergence of resistance to antiretroviral treatment after undisclosed prior exposure : a case report. Southern African Journal of HIV Medicine, (20(1):a965, doi:10.4102/sajhivmed.v20i1.965.
dc.descriptionThe original publication is available at http://www.sajhivmed.org.za/
dc.description.abstractIntroduction: Patients who disengaged from care may present as therapy naïve for antiretroviral treatment (ART) initiation at a different site, without being recognised as being at an increased risk of rapid treatment failure and HIV drug resistance. Patient presentation: A 43-year-old woman, who gave no prior history of ART, was initiated on a standard first-line regimen of TDF, FTC and EFV. She had a poor response to treatment with evidence of treatment failure at 12 months. Management and outcome: HIV-1 drug resistance tests showed no pre-treatment HIVDR mutations, but revealed high-level drug resistance to all component drugs at 12 months. On investigation, viral load (VL) was recorded in 2012 and 2013, providing evidence of prior ART use. Conclusion: Linkage of patient therapy and laboratory information to unique patient identifiers may allow health-care workers to identify patients who previously received ART and disengaged from care. This will enable differentiated care when these patients reinitiate ART, which should involve expedited VL testing and more rapid transition to definitive second-line ART.en_ZA
dc.description.urihttps://sajhivmed.org.za/index.php/hivmed/article/view/965
dc.description.versionPublisher's version
dc.format.extent3 pagesen_ZA
dc.identifier.citationRossouw, T. M., Van Dyk, G. & Van Zyl, G. 2019. Rapid emergence of resistance to antiretroviral treatment after undisclosed prior exposure : a case report. Southern African Journal of HIV Medicine, (20(1):a965, doi:10.4102/sajhivmed.v20i1.965
dc.identifier.issn2078-6751 (online)
dc.identifier.issn1608-9693 (print)
dc.identifier.otherdoi:10.4102/sajhivmed.v20i1.965
dc.identifier.urihttp://hdl.handle.net/10019.1/109597
dc.language.isoen_ZAen_ZA
dc.publisherAOSIS Publishingen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectHIV drug resistanceen_ZA
dc.subjectDrug resistanceen_ZA
dc.subjectAntiretroviral agentsen_ZA
dc.subjectHIV-infected personsen_ZA
dc.titleRapid emergence of resistance to antiretroviral treatment after undisclosed prior exposure : a case reporten_ZA
dc.typeArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
rossouw_rapid_2019.pdf
Size:
496.81 KB
Format:
Adobe Portable Document Format
Description:
Download article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Medical Virology)