The assessment of new anti-tuberculosis drugs for a paediatric indication

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dc.contributor.authorDonald P.R.
dc.date.accessioned2011-05-15T16:16:46Z
dc.date.available2011-05-15T16:16:46Z
dc.date.issued2007
dc.description.abstractFor the first time in three decades there is a promising pipeline of more than 20 new anti-tuberculosis agents at various stages of development, and several are already entering early clinical trials. Childhood tuberculosis (TB) comprises a significant part of the TB caseload, particularly in developing communities. There is, nonetheless, as yet no agreed pathway for the assessment of anti-tuberculosis agents in children. The feasibility of assessing an anti-tuberculosis agent in a childhood population is discussed in the present study, and it is concluded that it would be very difficult to assess the efficacy of an anti-tuberculosis agent in children due to the wide spectrum of diseases encountered in children and the lack of objective criteria to assess the response to treatment. However, it is essential that the pharmacokinetics and toxicity of any new agent should be assessed in a population of children over a range of ages. © 2007 The Union.
dc.description.versionReview
dc.identifier.citationInternational Journal of Tuberculosis and Lung Disease
dc.identifier.citation11
dc.identifier.citation11
dc.identifier.issn10273719
dc.identifier.urihttp://hdl.handle.net/10019.1/13928
dc.subjectchloramphenicol
dc.subjectisoniazid
dc.subjectpyrazinamide
dc.subjecttuberculostatic agent
dc.subjectchild care
dc.subjectclinical assessment
dc.subjectdrug efficacy
dc.subjectdrug half life
dc.subjecthuman
dc.subjectincidence
dc.subjectlung tuberculosis
dc.subjectmiliary tuberculosis
dc.subjectMycobacterium tuberculosis
dc.subjectpriority journal
dc.subjectreview
dc.subjecttreatment indication
dc.subjecttreatment outcome
dc.subjecttreatment response
dc.subjecttuberculous meningitis
dc.subjectunspecified side effect
dc.subjectAdolescent
dc.subjectAntitubercular Agents
dc.subjectChild
dc.subjectClinical Trials as Topic
dc.subjectHumans
dc.subjectTuberculosis
dc.titleThe assessment of new anti-tuberculosis drugs for a paediatric indication
dc.typeReview
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