Demyelinating disease of Schilder type in three young South African children: Dramatic response to corticosteroids

Simple item page
dc.contributor.authorPretorius M.-L.
dc.contributor.authorLoock D.B.
dc.contributor.authorRavenscroft A.
dc.contributor.authorSchoeman J.F.
dc.date.accessioned2011-05-15T16:16:53Z
dc.date.available2011-05-15T16:16:53Z
dc.date.issued1998
dc.description.abstractThree young children with the Schilder variant of multiple sclerosis were seen within a 3-year period at our hospital. The diagnosis was made on the basis of the typical (but not pathognomonic) clinical and magnetic resonance imaging (MRI) findings after eliminating other demyelinating and post-infectious disorders of the central nervous system. All three patients were treated with prednisone (2 mg/kg/day), which resulted in complete recovery in one patient and mild and moderate residual hemiparesis in the two other patients, respectively. Corticosteroid therapy was continued until the patients' neurologic condition normalized or no further clinical improvement occurred. No relapses were seen after discontinuation of corticosteroid treatment. Computed tomographic (CT) scan and MRI findings after completion of corticosteroid therapy were equally dramatic and corresponded with the clinical improvement. A strongly positive tuberculin skin test and a positive history of contact with adult tuberculosis in two of our patients raise the possibility of a connection between tuberculosis and Schilder's disease.
dc.description.versionArticle
dc.identifier.citationJournal of Child Neurology
dc.identifier.citation13
dc.identifier.citation5
dc.identifier.issn08830738
dc.identifier.urihttp://hdl.handle.net/10019.1/13978
dc.subjectcorticosteroid
dc.subjectdexamethasone
dc.subjectimmunoglobulin
dc.subjectprednisone
dc.subjectarticle
dc.subjectcase report
dc.subjectchild
dc.subjectclinical feature
dc.subjectcomputer assisted tomography
dc.subjectcorticosteroid therapy
dc.subjectdemyelinating disease
dc.subjectfemale
dc.subjecthuman
dc.subjectintravenous drug administration
dc.subjectmale
dc.subjectnuclear magnetic resonance imaging
dc.subjectoral drug administration
dc.subjectpreschool child
dc.subjectpriority journal
dc.subjectschool child
dc.subjecttreatment outcome
dc.subjectAnti-Inflammatory Agents
dc.subjectBrain
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectDiffuse Cerebral Sclerosis of Schilder
dc.subjectFemale
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectPrednisone
dc.subjectSouth Africa
dc.subjectTuberculosis
dc.titleDemyelinating disease of Schilder type in three young South African children: Dramatic response to corticosteroids
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Tygerberg Hospital Publications