Lack of interaction between α2-adrenoceptors and dopamine D2-receptors in mediating their inhibitory effects on [3H]dopamine release from rat nucleus accumbens slices

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dc.contributor.authorRussell V.A.
dc.contributor.authorLamm M.C.L.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:17:26Z
dc.date.available2011-05-15T16:17:26Z
dc.date.issued1993
dc.description.abstractThe α2-adrenoceptor agonist, UK14304, dose-dependently inhibited the electrically stimulated release of dopamine (DA) from rat nucleus accumbens slices. This effect was antagonized by idazoxan, confirming that it was an α2-adrenoceptor mediated effect. There was no evidence of endogenous activation of noradrenergic receptors suggesting that the α2-adrenoceptor agonist was not acting presynaptically to inhibit noradrenaline release. An in vitro superfusion technique was used to investigate whether there was any interaction between α2-adrenoceptors and DA D2-receptors in mediating their inhibitory effects on [3H]DA release from rat nucleus accumbens slices. α2-Adrenoceptors and DA D2-receptors interact with similar second messenger systems and it was considered that they may compete for a common pool of G-proteins. The inhibitory effects of the α2-adrenoceptor agonist, UK14304, and the DA receptor agonists, quinpirole, apomorphine and pergolide were not independent. However, there was no evidence of any interaction between UK14304 and the DA D2-receptor antagonists, sulpiride or haloperidol, suggesting that the two receptors do not compete for a common pool of G-proteins in mediating their inhibitory effects on DA release.
dc.description.versionArticle
dc.identifier.citationNeurochemical Research
dc.identifier.citation18
dc.identifier.citation3
dc.identifier.issn03643190
dc.identifier.other10.1007/BF00969084
dc.identifier.urihttp://hdl.handle.net/10019.1/14218
dc.subjectalpha 2 adrenergic receptor
dc.subjectapomorphine
dc.subjectbrimonidine
dc.subjectcitalopram
dc.subjectdesipramine
dc.subjectdopamine
dc.subjectdopamine 2 receptor
dc.subjectdopamine receptor blocking agent
dc.subjectdopamine receptor stimulating agent
dc.subjectguanine nucleotide binding protein
dc.subjecthaloperidol
dc.subjectidazoxan
dc.subjectpergolide
dc.subjectquinpirole
dc.subjectsulpiride
dc.subjecttritium
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectbrain slice
dc.subjectdepression
dc.subjectdopamine release
dc.subjectmale
dc.subjectnonhuman
dc.subjectnucleus accumbens
dc.subjectpriority journal
dc.subjectrat
dc.subjectsignal transduction
dc.subjecttissue perfusion
dc.subjectAdrenergic alpha-Agonists
dc.subjectAnimal
dc.subjectApomorphine
dc.subjectBinding, Competitive
dc.subjectDopamine
dc.subjectElectric Stimulation
dc.subjectErgolines
dc.subjectGTP-Binding Proteins
dc.subjectHaloperidol
dc.subjectIn Vitro
dc.subjectMale
dc.subjectNucleus Accumbens
dc.subjectPergolide
dc.subjectQuinoxalines
dc.subjectQuinpirole
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptors, Adrenergic, alpha
dc.subjectReceptors, Dopamine D2
dc.subjectSignal Transduction
dc.subjectSulpiride
dc.subjectSupport, Non-U.S. Gov't
dc.titleLack of interaction between α2-adrenoceptors and dopamine D2-receptors in mediating their inhibitory effects on [3H]dopamine release from rat nucleus accumbens slices
dc.typeArticle
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