Blood pressure patterns in pregnant patients on oral ketanserin

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dc.contributor.authorSteyn D.W.
dc.contributor.authorOdendaal H.J.
dc.date.accessioned2011-05-15T16:15:55Z
dc.date.available2011-05-15T16:15:55Z
dc.date.issued2001
dc.description.abstractBackground. Ketanserin, a selective serotonin-2 receptor antagonist, decreases systolic blood pressure (SBP) and diastolic blood pressure (DBP) in non-pregnant patients with hypertension, but not in normotensive subjects. Its effect on longitudinal blood pressure (BP) patterns in pregnant women has not been documented. Objectives. To assess how ketanserin, given orally, influences maternal BP during pregnancy. Design. A double-blind randomised controlled trial where patients with DBP ≥ 80 mmHg between 12 and 20 weeks' gestation received either ketanserin or placebo. Setting. Tygerberg Hospital, a tertiary referral unit in the Western Cape. Subjects. One hundred and two patients who received their study drug for at least 140 days during pregnancy. Patients requiring additional antihypertensive medication were excluded from the analysis. Outcome measures. Changes in SBP and DBP in relation to gestational age and days since entering the study. Results. The mean DBP over the total period was significantly lower in the ketanserin group (77 ± 8.7 mmHg v. 80.8 ± 9.1 mmHg). The decline in DBP was 9.2 mmHg in the ketanserin group and 5.3 mmHg in the placebo group. These differences were detected from within 7 days of therapy and persisted for most of the pregnancy. The mean SBP did not differ at any stage, although the mean fall in SBP was significantly greater in the ketanserin group (8.6 ± 16.7 v. 4.1 ± 17.1 mmHg). Conclusions. Ketanserin decreased DBP during pregnancy significantly more than placebo.
dc.description.versionArticle
dc.identifier.citationCardiovascular Journal of South Africa
dc.identifier.citation12
dc.identifier.citation2
dc.identifier.issn10159657
dc.identifier.urihttp://hdl.handle.net/10019.1/13551
dc.subjectantihypertensive agent
dc.subjectketanserin
dc.subjectmethyldopa
dc.subjectplacebo
dc.subjectarticle
dc.subjectblood pressure measurement
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdiastolic blood pressure
dc.subjectdose time effect relation
dc.subjectdouble blind procedure
dc.subjectdrug efficacy
dc.subjectdrug mechanism
dc.subjectfemale
dc.subjectgestational age
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmaternal hypertension
dc.subjectpregnancy complication
dc.subjectrandomized controlled trial
dc.subjectsecond trimester pregnancy
dc.subjectsystolic blood pressure
dc.subjectUnited States
dc.subjectAdministration, Oral
dc.subjectAntihypertensive Agents
dc.subjectBlood Pressure
dc.subjectDouble-Blind Method
dc.subjectFemale
dc.subjectGestational Age
dc.subjectHumans
dc.subjectHypertension
dc.subjectKetanserin
dc.subjectPregnancy
dc.titleBlood pressure patterns in pregnant patients on oral ketanserin
dc.typeArticle
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