Efficacy of fibrin sealant in prevention of adhesion formation on ovarian surgical wounds in a rabbit model

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dc.contributor.authorVandendael A.
dc.contributor.authorStruwig D.
dc.contributor.authorNel J.T.
dc.contributor.authorKruger T.F.
dc.contributor.authorLombard C.J.
dc.date.accessioned2011-05-15T16:16:29Z
dc.date.available2011-05-15T16:16:29Z
dc.date.issued1996
dc.description.abstractThe aim of the study was to determine whether the use of fibrin sealant decreases adhesion formation in ovarian surgical wounds in a rabbit model. A total of 20 female rabbits underwent a midline laparotomy. Microsurgical techniques were used to bivalve each ovary. After randomization one ovary was treated with fibrin sealant, while the other ovary served as a control. Prior to the study project a control group of 15 rabbits was included to study the effect of the laparotomy on the adhesion score of non-bivalved ovaries. At 3 weeks after surgery the adhesion scores were compared using the Wilcoxon signed rank test. The mean adhesion score of the fibrin sealant-treated ovaries (5.20 ± 1.24) was significantly different from the control ovaries (7.35 ± 2.32) (P = 0.0009; confidence intervals 95%). In our study we were able to demonstrate a benefit from using fibrin sealant to decrease postoperative adhesion formation of ovarian surgical wounds in a rabbit model. No influence of the laparotomy on the ovaries was shown. These findings can have applications in endoscopic surgery when procedures are performed on ovaries of human subjects.
dc.description.versionArticle
dc.identifier.citationGynaecological Endoscopy
dc.identifier.citation5
dc.identifier.citation3
dc.identifier.issn09621091
dc.identifier.urihttp://hdl.handle.net/10019.1/13801
dc.subjectfibrin
dc.subjectsealant
dc.subjectadhesion
dc.subjectanimal model
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectendoscopic surgery
dc.subjectfemale
dc.subjectlaparotomy
dc.subjectmicrosurgery
dc.subjectnonhuman
dc.subjectovary
dc.subjectpostoperative complication
dc.subjectpriority journal
dc.subjectrabbit
dc.subjectscoring system
dc.subjectstatistics
dc.subjectsurgical wound
dc.titleEfficacy of fibrin sealant in prevention of adhesion formation on ovarian surgical wounds in a rabbit model
dc.typeArticle
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