The application, mechanism of action and side-effects of immunosuppressive agents in clinical transplantation

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dc.contributor.authorDu Toit D. F.en_ZA
dc.contributor.authorHeydenrych J. J.en_ZA
dc.date.accessioned2011-03-18T14:57:31Z
dc.date.available2011-03-18T14:57:31Z
dc.date.issued1986-11
dc.descriptionCITATION: Du Toit, D.F. & Heydenrych, J.J. 1986. The application, mechanism of action and side-effects of immunosuppressive agents in clinical transplantation. S Afr Med J, 70(11):687-691.en_ZA
dc.descriptionThe original publication is available at http://www.samj.org.zaen_ZA
dc.description.abstractENGLISH ABSTRACT: The conventional agents (azathioprine and steroids) have been the mainstay of organ allograft immunosuppression for the past 20 years. The main drawback of the immunosuppressive agents at present in use is that they act nonspecifically with sequential general depression of the immune system. The introduction of cyclosporin, an undecapeptide of fungal origin, which selectively inhibits T-cell-dependent immunoreaction has made a significant impact on organ allograft survival rates. Clinical application has been complicated because of renal or hepatotoxicity. Thoracic duct drainage is of historical interest but the use of antilymphocyte serum, despite its chequered history, has recently been shown to be safe and effective in cadaver kidney transplant recipients. There has also been a resurgence of interest in the use of total lymphoid irradiation as an immunosuppressive agent. The introduction of xenogenic monoclonal antibodies with anti-T-cell specificity opened a new era in clinical immunology and OKT3-PAN has emerged as a powerful major immunosuppressive agent with low toxicity.en_ZA
dc.description.versionPublisher’s version
dc.format.extent5 pagesen_ZA
dc.identifier.citationDu Toit, D.F. & Heydenrych, J.J. 1986. The application, mechanism of action and side-effects of immunosuppressive agents in clinical transplantation. S Afr Med J, 70(11):687-691.en_ZA
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7471
dc.language.isoen_ZAen_ZA
dc.publisherHealth & Medical Publishing Groupen_ZA
dc.rights.holderSouth African Medical Journalen_ZA
dc.subjectImmunosuppressive agentsen_ZA
dc.subjectImmunosuppressiveen_ZA
dc.subjectTransplantation immunologyen_ZA
dc.titleThe application, mechanism of action and side-effects of immunosuppressive agents in clinical transplantationen_ZA
dc.typeArticleen_ZA
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