Maternal and infant outcomes among pregnant women treated for multidrug/rifampicin-resistant tuberculosis in South Africa

Simple item page
dc.contributor.authorLoveday, Marianen_ZA
dc.contributor.authorHughes, Jenniferen_ZA
dc.contributor.authorSunkari, Babuen_ZA
dc.contributor.authorMaster, Iqbalen_ZA
dc.contributor.authorHlangu, Sindisiween_ZA
dc.contributor.authorReddy, Taryleeen_ZA
dc.contributor.authorChotoo, Sunithaen_ZA
dc.contributor.authorGreen, Nathanen_ZA
dc.contributor.authorSeddon, James Aen_ZA
dc.date.accessioned2023-05-10T09:30:01Zen_ZA
dc.date.available2023-05-10T09:30:01Zen_ZA
dc.date.issued2021-04en_ZA
dc.descriptionCITATION: Marian Loveday, Jennifer Hughes, Babu Sunkari, Iqbal Master, Sindisiwe Hlangu, Tarylee Reddy, Sunitha Chotoo, Nathan Green, James A Seddon, Maternal and Infant Outcomes Among Pregnant Women Treated for Multidrug/Rifampicin-Resistant Tuberculosis in South Africa, Clinical Infectious Diseases 72(7):1158–1168 pages, doi.10.1093/cid/ciaa189en_ZA
dc.descriptionThe original publication is available at: academic.oup.comen_ZA
dc.description.abstractBackground Data on safety and efficacy of second-line tuberculosis drugs in pregnant women and their infants are severely limited due to exclusion from clinical trials and expanded access programs. Methods Pregnant women starting treatment for multidrug/rifampicin-resistant (MDR/RR)-tuberculosis at King Dinuzulu Hospital in KwaZulu-Natal, South Africa, from 1 January 2013 to 31 December 2017, were included. We conducted a record review to describe maternal treatment and pregnancy outcomes, and a clinical assessment to describe infant outcomes. Results Of 108 pregnant women treated for MDR/RR-tuberculosis, 88 (81%) were living with human immunodeficiency virus.. Favorable MDR/RR-tuberculosis treatment outcomes were reported in 72 (67%) women. Ninety-nine (91%) of the 109 babies were born alive, but overall, 52 (48%) women had unfavorable pregnancy outcomes. Fifty-eight (54%) women received bedaquiline, and 49 (45%) babies were exposed to bedaquiline in utero. Low birth weight was reported in more babies exposed to bedaquiline compared to babies not exposed (45% vs 26%; P = .034). In multivariate analyses, bedaquiline and levofloxacin, drugs often used in combination, were both independently associated with increased risk of low birth weight. Of the 86 children evaluated at 12 months, 72 (84%) had favorable outcomes; 88% of babies exposed to bedaquiline were thriving and developing normally compared to 82% of the babies not exposed. Conclusions MDR/RR-tuberculosis treatment outcomes among pregnant women were comparable to nonpregnant women. Although more babies exposed to bedaquiline were of low birth weight, over 80% had gained weight and were developing normally at 1 year.en_ZA
dc.description.versionPublisher’s versionen_ZA
dc.format.extent11 pagesen_ZA
dc.identifier.citationMarian Loveday, Jennifer Hughes, Babu Sunkari, Iqbal Master, Sindisiwe Hlangu, Tarylee Reddy, Sunitha Chotoo, Nathan Green, James A Seddon, Maternal and Infant Outcomes Among Pregnant Women Treated for Multidrug/Rifampicin-Resistant Tuberculosis in South Africa, Clinical Infectious Diseases 72(7):1158–1168 pages, doi.10.1093/cid/ciaa189en_ZA
dc.identifier.issn1058-4838 (print)en_ZA
dc.identifier.issn1537-6591 (online)en_ZA
dc.identifier.otherdoi.10.1093/cid/ciaa189en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/126887en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherOxford University Pressen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectMultidrug-resistant tuberculosis -- South Africaen_ZA
dc.subjectPregnant women -- South Africaen_ZA
dc.subjectMaternal health services -- South Africaen_ZA
dc.subjectClinical trials -- South Africaen_ZA
dc.titleMaternal and infant outcomes among pregnant women treated for multidrug/rifampicin-resistant tuberculosis in South Africaen_ZA
dc.typeArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
marian_maternal_2021.pdf
Size:
1.31 MB
Format:
Adobe Portable Document Format
Description:
download article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Paediatrics and Child Health)