Comparing axillary and mediastinal lymphadenopathy on CT in children with suspected pulmonary tuberculosis

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dc.contributor.authorTheron S.
dc.contributor.authorAndronikou S.
dc.date.accessioned2011-05-15T16:17:42Z
dc.date.available2011-05-15T16:17:42Z
dc.date.issued2005
dc.description.abstractBackground: Radiographic demonstration of mediastinal lymphadenopathy is important for the diagnosis of pulmonary tuberculosis (PTB). Plain radiographs are unreliable for this and CT, which is relatively more expensive and carries a high radiation burden, remains the gold standard. No studies correlating the presence of axillary with mediastinal lymphadenopathy have been reported. Such a correlation would allow for clinical or ultrasound diagnosis of PTB via the axilla. Objective: To correlate the presence of axillary lymphadenopathy with mediastinal lymphadenopathy in children with suspected PTB. Materials and methods: CT scans were performed and reviewed in 100 children (prospectively recruited) with suspected PTB. The axilla and mediastinum were reviewed separately by covering the non-relevant sections on the CT scans prior to reading. Only nodes greater than 1 cm were regarded as pathological. Results: Mediastinal lymphadenopathy was present in 46% of children; 70% had lymphadenopathy in either axilla. Bilateral axillary lymphadenopathy was identified in 47%. Axillary lymphadenopathy showed a sensitivity of 74% and a specificity of 33% for the presence of mediastinal adenopathy. Bilateral axillary adenopathy had a sensitivity of 50% and a specificity of 56%. Conclusions: Axillary lymphadenopathy has a moderate sensitivit y and low specificity for the presence of mediastinal and hilar lymphadenopathy in children with suspected PTB. Further research should be aimed at correlating ultrasound-detected axillary lymphadenopathy with FNA results in children. © Springer-Verlag 2005.
dc.description.versionArticle
dc.identifier.citationPediatric Radiology
dc.identifier.citation35
dc.identifier.citation9
dc.identifier.issn03010449
dc.identifier.other10.1007/s00247-005-1490-y
dc.identifier.urihttp://hdl.handle.net/10019.1/14336
dc.subjectarticle
dc.subjectaxillary lymph node
dc.subjectchild care
dc.subjectclinical trial
dc.subjectcomputer assisted tomography
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectfemale
dc.subjecthuman
dc.subjectinfant
dc.subjectlung tuberculosis
dc.subjectlymphadenopathy
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmediastinum lymph node
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectsensitivity and specificity
dc.subjectAxilla
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectHumans
dc.subjectInfant
dc.subjectLymphatic Diseases
dc.subjectMale
dc.subjectMediastinum
dc.subjectPredictive Value of Tests
dc.subjectProspective Studies
dc.subjectSensitivity and Specificity
dc.subjectTomography, X-Ray Computed
dc.subjectTuberculosis, Lymph Node
dc.subjectTuberculosis, Pulmonary
dc.titleComparing axillary and mediastinal lymphadenopathy on CT in children with suspected pulmonary tuberculosis
dc.typeArticle
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