Platelet, monocyte and neutrophil activation and glucose tolerance in South African Mixed Ancestry individuals

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dc.contributor.authorDavison, Glenda M.en_ZA
dc.contributor.authorNkambule, Bongani B.en_ZA
dc.contributor.authorMkandla, Zibusisoen_ZA
dc.contributor.authorHon, Gloudina M.en_ZA
dc.contributor.authorKengne, Andre P.en_ZA
dc.contributor.authorErasmus, Rajiv T.en_ZA
dc.contributor.authorMatsha, Tandi E.en_ZA
dc.date.accessioned2018-11-30T06:24:25Z
dc.date.available2018-11-30T06:24:25Z
dc.date.issued2017
dc.descriptionCITATION: Davison, G. M., et al. 2017. Platelet, monocyte and neutrophil activation and glucose tolerance in South African Mixed Ancestry individuals. Scientific Reports, 7:40329, doi:10.1038/srep40329.en_ZA
dc.descriptionThe original publication is available at https://www.nature.comen_ZA
dc.description.abstractPlatelet activation has been described in patients with chronic inflammation, however in type 2 diabetes mellitus it remains controversial. We compared levels of platelet leucocyte aggregates, monocyte and granulocyte activation across glucose tolerance statuses in mixed ancestry South Africans. Individuals (206) were recruited from Bellville-South, Cape Town, and included 66% with normal glucose tolerance, 18.7% pre-diabetes, 8.7% screen-detected diabetes and 6.3% known diabetes. Monocyte and neutrophil activation were measured by calculating the percentage of cells expressing CD142 and CD69 while platelet monocyte aggregates were defined as CD14++ CD42b+ events and platelet neutrophil aggregates as CD16++ CD42b+ events. The percentage of monocytes and neutrophils expressing CD69 and CD142 was significantly higher in known diabetes and prediabetes, but, lowest in screen-detected diabetes (both p ≤ 0.016). The pattern was similar for platelet monocyte and neutrophil aggregates (both p ≤ 0.003). In robust linear regressions adjusted for age and gender, known diabetes was significantly and positively associated with the percentage of monocytes expressing CD69 [beta 11.06 (p = 0.016)] and CD42b (PMAs) [19.51 (0.003)] as well as the percentage of neutrophils expressing CD69 [14.19 (<0.0001)] and CD42b [17.7 (0.001)]. We conclude that monitoring platelet activation in diagnosed diabetic patients may have a role in the management and risk stratification.en_ZA
dc.description.urihttps://www.nature.com/articles/srep40329
dc.description.versionPublisher's versionen_ZA
dc.format.extent9 pagesen_ZA
dc.identifier.citationCITATION: Davison, G. M., et al. 2017. Platelet, monocyte and neutrophil activation and glucose tolerance in South African Mixed Ancestry individuals. Scientific Reports, 7:40329, doi:10.1038/srep40329.en_ZA
dc.identifier.issn2045-2322 (online)
dc.identifier.otherdoi:10.1038/srep40329
dc.identifier.urihttp://hdl.handle.net/10019.1/104753
dc.language.isoen_ZAen_ZA
dc.publisherNature Researchen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectBlood plateletsen_ZA
dc.subjectDiabetes -- Researchen_ZA
dc.subjectMonocytesen_ZA
dc.subjectNeutrophil activationen_ZA
dc.subjectGlucose toleranceen_ZA
dc.titlePlatelet, monocyte and neutrophil activation and glucose tolerance in South African Mixed Ancestry individualsen_ZA
dc.typeArticleen_ZA
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