Tremor in Parkinson's disease

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dc.contributor.authorCarr J.
dc.date.accessioned2011-05-15T16:17:35Z
dc.date.available2011-05-15T16:17:35Z
dc.date.issued2002
dc.description.abstractRest tremor is a common feature of Parkinson's disease, but its underlying pathophysiology remains unknown. This review hypothesizes that tremor is related to selective loss of components of the substantia nigra. The relative scarcity of tremor in related Parkinsonian conditions may indicate a dissociation associated with different pathological involvement of the substantia nigra and its connections. Connections of the subthalamic nucleus with the pallidum, modified by cortical and nigral inputs, allow for the transfer of tremorogenic activity to the thalamus. Thalamo-cortical interactions, tempered by cerebellar input, generate the final common pathway for tremor production. © 2002 Elsevier Science Ltd. All rights reserved.
dc.description.versionReview
dc.identifier.citationParkinsonism and Related Disorders
dc.identifier.citation8
dc.identifier.citation4
dc.identifier.issn13538020
dc.identifier.other10.1016/S1353-8020(01)00037-2
dc.identifier.urihttp://hdl.handle.net/10019.1/14281
dc.subjectclinical feature
dc.subjectglobus pallidus
dc.subjecthuman
dc.subjectParkinson disease
dc.subjectpathophysiology
dc.subjectpriority journal
dc.subjectreview
dc.subjectsubstantia nigra
dc.subjectsubthalamic nucleus
dc.subjectthalamocortical tract
dc.subjectthalamus
dc.subjecttremor
dc.subjectAnimals
dc.subjectCerebral Cortex
dc.subjectHumans
dc.subjectModels, Neurological
dc.subjectParkinson Disease
dc.subjectSubstantia Nigra
dc.subjectThalamus
dc.subjectTremor
dc.titleTremor in Parkinson's disease
dc.typeReview
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