Physical exercise potentially targets epicardial adipose tissue to reduce cardiovascular disease risk in patients with metabolic diseases : oxidative stress and inflammation emerge as major therapeutic targets

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dc.contributor.authorNyawo, Thembeka A.en_ZA
dc.contributor.authorPheiffer, Carmenen_ZA
dc.contributor.authorMazibuko-Mbeje, Sithandiwe Een_ZA
dc.contributor.authorMthembu, Sinenhlanhla X. H.en_ZA
dc.contributor.authorNyambuya, Tawanda M.en_ZA
dc.contributor.authorNkambule, Bongani B.en_ZA
dc.contributor.authorSadie-Van Gijsen, Hanelen_ZA
dc.contributor.authorStrijdom, Hansen_ZA
dc.contributor.authorTiano, Lucaen_ZA
dc.contributor.authorDludla, Phiwayinkosi V.en_ZA
dc.date.accessioned2022-01-04T09:29:29Z
dc.date.available2022-01-04T09:29:29Z
dc.date.issued2021-11-04
dc.descriptionCITATION: Nyawo, T. A. et al. 2021. Physical exercise potentially targets epicardial adipose tissue to reduce cardiovascular disease risk in patients with metabolic diseases : oxidative stress and inflammation emerge as major therapeutic targets. Antioxidants, 10(11):1758, doi:10.3390/antiox10111758.
dc.descriptionThe original publication is available at https://www.mdpi.com
dc.description.abstractENGLISH ABSTRACT: Excess epicardial adiposity, within a state of obesity and metabolic syndrome, is emerging as an important risk factor for the development of cardiovascular diseases (CVDs). Accordingly, increased epicardial fat thickness (EFT) implicates the exacerbation of pathological mechanisms involving oxidative stress and inflammation within the heart, which may accelerate the development of CVDs. This explains increased interest in targeting EFT reduction to attenuate the detrimental effects of oxidative stress and inflammation within the setting of metabolic syndrome. Here, we critically discuss clinical and preclinical evidence on the impact of physical exercise on EFT in correlation with reduced CVD risk within a setting of metabolic disease. This review also brings a unique perspective on the implications of oxidative stress and inflammation as major pathological consequences that link increased EFT to accelerated CVD risk in conditions of metabolic disease.en_ZA
dc.description.urihttps://www.mdpi.com/2076-3921/10/11/1758
dc.description.versionPublisher's version
dc.format.extent16 pagesen_ZA
dc.identifier.citationNyawo, T. A. et al. 2021. Physical exercise potentially targets epicardial adipose tissue to reduce cardiovascular disease risk in patients with metabolic diseases : oxidative stress and inflammation emerge as major therapeutic targets. Antioxidants, 10(11):1758, doi:10.3390/antiox10111758.
dc.identifier.issn2076-3921 (online)
dc.identifier.otherdoi:10.3390/antiox10111758
dc.identifier.urihttp://hdl.handle.net/10019.1/124038
dc.language.isoen_ZAen_ZA
dc.publisherMDPIen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectExerciseen_ZA
dc.subjectAdipose tissuesen_ZA
dc.subjectEpicardial adipose tissueen_ZA
dc.subjectCardiovascular system -- Diseasesen_ZA
dc.subjectOxidative Stresen_ZA
dc.subjectCardiovascular Diseases -- Risk factorsen_ZA
dc.titlePhysical exercise potentially targets epicardial adipose tissue to reduce cardiovascular disease risk in patients with metabolic diseases : oxidative stress and inflammation emerge as major therapeutic targetsen_ZA
dc.typeArticleen_ZA
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