The effect of anthracyclines on myocardial function in 50 long-term survivors of childhood cancer

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dc.contributor.authorHesseling P.B.
dc.contributor.authorKalis N.N.
dc.contributor.authorWessels G.
dc.contributor.authorVan Der Merwe P.-L.
dc.date.accessioned2011-05-15T16:15:56Z
dc.date.available2011-05-15T16:15:56Z
dc.date.issued1998
dc.description.abstractAnthracyclines, which are effective in the treatment of childhood cancer, are known for their cardiotoxicity. In this study, with a mean follow-up of 116 months, the adverse effects of anthracyclines on conduction and myocardial function were evaluated by means of electrocardiography and echocardiography. ECG abnormalities, present in 2 patients, were nonspecific ST-segment and T-wave changes; cardiac function was normal. Echocardiographic abnormalities were present in 1 patient. He had a shortening fraction of less than 25% and presented in cardiac failure. Cardiotoxic effects of anthracyclines used in doses according to standard treatment protocols were minimal in this long-term follow-up study. Routine ECG and echocardiography in asymptomatic patients during long-term follow-up are not indicated when an anthracycline dose of less than 450 mg/m2 has been used and concomitant radiotherapy has not been administered.
dc.description.versionArticle
dc.identifier.citationCardiovascular Journal of South Africa
dc.identifier.citation89
dc.identifier.citation1
dc.identifier.issn10159657
dc.identifier.urihttp://hdl.handle.net/10019.1/13557
dc.subjectanthracycline derivative
dc.subjectantineoplastic agent
dc.subjectadolescent
dc.subjectadult
dc.subjectarticle
dc.subjectcardiotoxicity
dc.subjectchild
dc.subjectchildhood cancer
dc.subjectclinical article
dc.subjectfemale
dc.subjectheart failure
dc.subjectheart function
dc.subjecthuman
dc.subjectmale
dc.subjectST segment
dc.subjectt wave
dc.titleThe effect of anthracyclines on myocardial function in 50 long-term survivors of childhood cancer
dc.typeArticle
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