Warthin's tumour is not an Epstein-Barr virus related disease

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dc.contributor.authorVan Heerden W.F.P.
dc.contributor.authorKraft K.
dc.contributor.authorHemmer J.
dc.contributor.authorSwart T.J.P.
dc.contributor.authorVan Heerden M.B.
dc.contributor.authorVan Rensburg E.J.
dc.date.accessioned2011-05-15T16:15:33Z
dc.date.available2011-05-15T16:15:33Z
dc.date.issued1999
dc.description.abstractBackground: The histogenesis of Warthin's tumour (WT) is controversial. A possible role for Epstein-Barr virus (EBV) has been suggested. Materials and Methods: Twenty formaldehyde-fixed, paraffin-embedded blocks of WT from the parotid gland were examined for the presence of EBV. In situ hybridisation was performed using EBV encoded small nuclear RNAs (EBER1/2) probes labelled with fluorescein isothiocyanate. An EBV-positive P3HR-1 cell line processed to paraffin wax was used as a positive control and a brain section as negative control. Results: EBER1/2 could not be found in the neoplastic epithelial cells in any of the tumours nor in the adjacent normal parotid tissues. Individual positive lymphocytes were present in 7 tumours. Conclusions: These results indicated that EBV is not involved in the pathogenesis of WT.
dc.description.versionArticle
dc.identifier.citationAnticancer Research
dc.identifier.citation19
dc.identifier.citation4 B
dc.identifier.issn02507005
dc.identifier.urihttp://hdl.handle.net/10019.1/13385
dc.subjectfluorescein isothiocyanate
dc.subjectparaffin
dc.subjectsmall nuclear RNA
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectcell line
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectepithelium cell
dc.subjectEpstein Barr virus
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectin situ hybridization
dc.subjectlymphocyte
dc.subjectmale
dc.subjectparotid gland
dc.subjectpathogenesis
dc.subjectpriority journal
dc.subjectWarthin tumor
dc.subjectAdenolymphoma
dc.subjectHerpesvirus 4, Human
dc.subjectHumans
dc.subjectIn Situ Hybridization
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRNA, Viral
dc.titleWarthin's tumour is not an Epstein-Barr virus related disease
dc.typeArticle
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