Free radical scavenging effects of melatonin and serotonin: Possible mechanism

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dc.contributor.authorDaniels W.M.U.
dc.contributor.authorVan Rensburg S.J.
dc.contributor.authorVan Zyl J.M.
dc.contributor.authorVan Der Walt B.J.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:17:30Z
dc.date.available2011-05-15T16:17:30Z
dc.date.issued1996
dc.description.abstractMelatonin has been reported to be a potent free radical scavenger, but the mechanism by which it protects membranes from lipid peroxidation is poorly understood. The present study addresses this problem by comparing the free radical scavenging properties of melatonin and serotonin, two indoles with similar structure, but differing solubilities. Both serotonin and melatonin significantly prevented lipid peroxidation of platelet membranes. Additionally, melatonin significantly decreased the microviscosity (increased the fluidity) of platelet membranes, while serotonin had the opposite effect. These data led us to postulate that serotonin exerts its free radical scavenging action in the aqueous phase, or at the water-membrane interface, while melatonin positions itself within the lipid bilayer where it protects membrane phospholipids against free radical attack.
dc.description.versionArticle
dc.identifier.citationNeuroReport
dc.identifier.citation7
dc.identifier.citation10
dc.identifier.issn09594965
dc.identifier.urihttp://hdl.handle.net/10019.1/14242
dc.subjectfree radical
dc.subjectmelatonin
dc.subjectserotonin
dc.subjectalzheimer disease
dc.subjectarticle
dc.subjectcontrolled study
dc.subjecthuman
dc.subjecthuman cell
dc.subjectlipid peroxidation
dc.subjectmembrane fluidity
dc.subjectpriority journal
dc.subjectthrombocyte
dc.subjectCell Membrane
dc.subjectDose-Response Relationship, Drug
dc.subjectFree Radical Scavengers
dc.subjectHumans
dc.subjectLipid Peroxidation
dc.subjectMelatonin
dc.subjectSerotonin
dc.titleFree radical scavenging effects of melatonin and serotonin: Possible mechanism
dc.typeArticle
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