Predominance of Central Asian strain (ST 26) in Mycobacterium tuberculosis isolates from Balochistan by spoligotyping

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dc.contributor.authorShafee, Muhammaden_ZA
dc.contributor.authorAbbas, Ferhaten_ZA
dc.contributor.authorTanveer, Zuneraen_ZA
dc.contributor.authorWhitelaw, Andrewen_ZA
dc.contributor.authorTow, Lemese Ahen_ZA
dc.contributor.authorAshraf, Muhammaden_ZA
dc.contributor.authorAhmad, Irshaden_ZA
dc.contributor.authorPatching, Simon G.en_ZA
dc.contributor.authorJabbar, Abdulen_ZA
dc.contributor.authorAkbar, Alien_ZA
dc.contributor.authorMustafa, Mohammad Zahiden_ZA
dc.date.accessioned2021-07-08T11:32:58Z
dc.date.available2021-07-08T11:32:58Z
dc.date.issued2019-07
dc.descriptionCITATION: Shafee, M. et al. 2019. Predominance of Central Asian strain (ST 26) in Mycobacterium tuberculosis isolates from Balochistan by spoligotyping. Journal of Infection in Developing Countries, 13(7):619-625, doi:10.3855/jidc.10803.
dc.descriptionThe original publication is available at https://jidc.org
dc.description.abstractIntroduction: Tuberculosis is a chronic debilitating infectious disease causing a severe challenge to public health, especially in developing countries. The aim of this study was to examine genetic diversity in Mycobacterium tuberculosis strains circulating in the Balochistan region of Pakistan. Methodology: One hundred isolates collected from patients visiting the Fatima Jinnah TB Hospital in Quetta were subjected to genotype analysis by spoligotyping. Results: Three main genotypes were identified: Central Asian Strain 1 (CAS1) (n = 89), East African Indian (EAI) strain (n = 7) and Latin American Mediterranean (LAM) strain (n = 3). The CAS1 clade (ST 26) had high genetic diversity represented by seven different spoligopatterns, of which one had major predominace (n = 75). Conclusions: This is the first insight into the genotype of M. tuberculosis strains in the Balochistan region that might serve as a base line study for control of tuberculosis in the community.en_ZA
dc.description.urihttps://jidc.org/index.php/journal/article/view/10803
dc.description.versionPublisher's version
dc.format.extent7 pages
dc.identifier.citationShafee, M. et al. 2019. Predominance of Central Asian strain (ST 26) in Mycobacterium tuberculosis isolates from Balochistan by spoligotyping. Journal of Infection in Developing Countries, 13(7):619-625, doi:10.3855/jidc.10803.
dc.identifier.issn1972-2680 (online)
dc.identifier.otherdoi:10.3855/jidc.10803
dc.identifier.urihttp://hdl.handle.net/10019.1/110680
dc.language.isoen_ZAen_ZA
dc.publisherJIDC
dc.rights.holderAuthors retain copyright
dc.subjectTuberculosis -- Central Asian -- Balochistanen_ZA
dc.subjectMycobacterium tuberculosis -- Genetic aspectsen_ZA
dc.subjectGenotype-environment interaction -- Analysisen_ZA
dc.subjectSpoligotypingen_ZA
dc.titlePredominance of Central Asian strain (ST 26) in Mycobacterium tuberculosis isolates from Balochistan by spoligotypingen_ZA
dc.typeArticleen_ZA
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