Light-driven proton transfer for cyclic and temporal switching of enzymatic nanoreactors

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dc.contributor.authorMoreno, Silviaen_ZA
dc.contributor.authorSharan, Priyankaen_ZA
dc.contributor.authorEngelke, Johannaen_ZA
dc.contributor.authorGumz, Hannesen_ZA
dc.contributor.authorBoye, Susanneen_ZA
dc.contributor.authorOertel, Ulrichen_ZA
dc.contributor.authorWang, Pengen_ZA
dc.contributor.authorBanerjee, Susantaen_ZA
dc.contributor.authorKlajn, Rafalen_ZA
dc.contributor.authorVoit, Brigitteen_ZA
dc.contributor.authorLederer, Albenaen_ZA
dc.contributor.authorAppelhans, Dietmaren_ZA
dc.date.accessioned2023-01-18T06:10:04Zen_ZA
dc.date.available2023-01-18T06:10:04Zen_ZA
dc.date.issued2020-08en_ZA
dc.descriptionCITATION: Moreno, S. et al. 2020. Light-driven proton transfer for cyclic and temporal switching of enzymatic nanoreactors. Small, 16:2002135, doi:10.1002/smll.202002135.en_ZA
dc.descriptionThe original publication is available at https://onlinelibrary.wiley.comen_ZA
dc.description.abstractTemporal activation of biological processes by visible light and subsequent return to an inactive state in the absence of light is an essential characteristic of photoreceptor cells. Inspired by these phenomena, light-responsive materials are very attractive due to the high spatiotemporal control of light irradiation, with light being able to precisely orchestrate processes repeatedly over many cycles. Herein, it is reported that light-driven proton transfer triggered by a merocyanine-based photoacid can be used to modulate the permeability of pH-responsive polymersomes through cyclic, temporally controlled protonation and deprotonation of the polymersome membrane. The membranes can undergo repeated light-driven swelling–contraction cycles without losing functional effectiveness. When applied to enzyme loaded-nanoreactors, this membrane responsiveness is used for the reversible control of enzymatic reactions. This combination of the merocyanine-based photoacid and pH-switchable nanoreactors results in rapidly responding and versatile supramolecular systems successfully used to switch enzymatic reactions ON and OFF on demand.en_ZA
dc.description.versionPublisher's versionen_ZA
dc.format.extent12 pagesen_ZA
dc.identifier.citationMoreno, S. et al. 2020. Light-driven proton transfer for cyclic and temporal switching of enzymatic nanoreactors. Small, 16:2002135, doi:10.1002/smll.202002135.en_ZA
dc.identifier.issn1613-6829 (online)en_ZA
dc.identifier.otherdoi:10.1002/smll.202002135en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/126221en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherWiley Onlineen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectProton transferen_ZA
dc.subjectEnzymes -- Reactivityen_ZA
dc.subjectPhotoreceptor cellsen_ZA
dc.titleLight-driven proton transfer for cyclic and temporal switching of enzymatic nanoreactorsen_ZA
dc.typeArticleen_ZA
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