Treatment of onyalai with prednisolone, intravenous gammaglobulin and ascorbic acid. A prospective clinical trial

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dc.contributor.authorHesseling P. B.
dc.contributor.authorGirdle-Brown B.
dc.contributor.authorOosthuysen E.
dc.contributor.authorSmit J.
dc.date.accessioned2011-03-18T14:59:44Z
dc.date.available2011-03-18T14:59:44Z
dc.date.issued1984
dc.descriptionArticleen_ZA
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractForty-two patients in the acute phase of onyalai were admitted to hospital and randomly divided into three groups of 14 to receive prednisolone 3 mg/kg/d for 1 week, intravenous gammaglobulin 100 mg/kg on 2 successive days, or ascorbic acid 1,000 mg 3 times a day for 1 week. The groups were comparable with regard to sex and age distribution, initial platelet counts and initial haemoglobin values. No statistical difference was observed between the three treatment groups with regard to changes in the platelet counts during the period of observation. One patient died from haemorrhagic shock. The low mortality rate in this series suggests that admission to hospital and early correction of blood loss are important factors in reducing the mortality rate associated with onyalai.en_ZA
dc.description.sponsorshipThis work was supported by a grant from the South African Medical Research Council (SAMRC) and aided by the Cape provincial Administrationen_ZA
dc.description.versionPublishers’ version
dc.format.extentpp. 916-917
dc.identifierISSN: 2078-5135 (online)
dc.identifier0256-9574 (print)
dc.identifier.citationHesseling, P.B., Girdle-Brown, B., Oosthuysen, E., Smit, J. 1984. Treatment of onyalai with prednisolone, intravenous gammaglobulin and ascorbic acid: a prospective clinical trial. South African Medical Journal, 66, 15 December, 916-917.en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/8019
dc.language.isoen_ZA
dc.publisherHMPG
dc.rights.holderThe authors
dc.subjectBlood and hemopoietic systemen_ZA
dc.subjectIdiopathic thrombocytopenic purpuraen_ZA
dc.subjectPeripheral vascular systemen_ZA
dc.subjectThrombocytopeniaen_ZA
dc.subjectAscorbic Aciden_ZA
dc.subjectChild, Preschoolen_ZA
dc.subjectCorticotropinen_ZA
dc.subjectDrug therapy, Combinationen_ZA
dc.subjectImmunization, Passiveen_ZA
dc.subjectPlatelet Counten_ZA
dc.subjectPrednisoloneen_ZA
dc.subjectPurpura, Thrombocytopenicen_ZA
dc.subjectIntravenous gammaglobulin therapyen_ZA
dc.subjectHaemorrhagic Bullae -- Treatment -- Namibia -- Kavangoen_ZA
dc.subjectOnyalai -- Diagnosis -- Namibia -- Kavangoen-ZA
dc.subjectOnyalai -- Treatment -- Namibia -- Kavangoen_ZA
dc.subjectAscorbic acid -- Therapyen_ZA
dc.subjectPrednisolone -- Therapyen_ZA
dc.subjectThrombocytopenia -- Genetic aspectsen_ZA
dc.subject.corpRundu State Hospital -- Namibia -- Kavangoen_ZA
dc.subject.lcshBlood platelets -- Transfusionen_ZA
dc.subject.lcshIntravenous therapy -- Complicationsen_ZA
dc.titleTreatment of onyalai with prednisolone, intravenous gammaglobulin and ascorbic acid. A prospective clinical trialen_ZA
dc.typeArticleen_ZA
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