The impact of sugar-sweetened beverage consumption on the liver : a proteomics-based analysis

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dc.contributor.authorBenade, Janinaen_ZA
dc.contributor.authorSher, Lucienen_ZA
dc.contributor.authorDe Klerk, Sheneezen_ZA
dc.contributor.authorDeshpande, Gaurangen_ZA
dc.contributor.authorBester, Dirken_ZA
dc.contributor.authorMarnewick, Jeanine L.en_ZA
dc.contributor.authorSieck, Garyen_ZA
dc.contributor.authorLaher, Ismailen_ZA
dc.contributor.authorEssop, M. Faadielen_ZA
dc.date.accessioned2021-09-07T09:35:01Z
dc.date.available2021-09-07T09:35:01Z
dc.date.issued2020
dc.descriptionCITATION: Benade, J., et al. 2020. The impact of sugar-sweetened beverage consumption on the liver : a proteomics-based analysis. Antioxidants, 9(7):569, doi:10.3390/antiox9070569.
dc.descriptionThe original publication is available at https://www.mdpi.com/journal/antioxidants
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund
dc.description.abstractCardiometabolic complications such as the metabolic syndrome and Type 2 Diabetes Mellitus (T2DM) are major causes of global morbidity and mortality. As sugar-sweetened beverages (SSBs) are implicated in this process, this study aimed to obtain greater mechanistic insights. Male Wistar rats (~200 g) were gavaged with a local SSB every day for a period of six months while the control group was gavaged with an iso-volumetric amount of water. Experimental dosages were calculated according to the surface area-to-volume ratio and were equivalent to 125 mL/day (in human terms). A proteomic analysis was performed on isolated liver samples and thereafter, markers of endoplasmic reticulum (ER) stress, antioxidant/oxidant capacity, calcium regulation, and mitochondrial functionality were assessed. These data show that SSB consumption resulted in (a) the induction of mild hepatic ER stress; (b) altered hepatic mitochondrial dynamics; and (c) perturbed calcium handling across mitochondria-associated ER membranes. Despite significant changes in markers of ER stress, the antioxidant response and calcium handling (proteomics data), the liver is able to initiate adaptive responses to counteract such stressors. However, the mitochondrial data showed increased fission and decreased fusion that may put the organism at risk for developing insulin resistance and T2DM in the longer term.en_ZA
dc.description.urihttps://www.mdpi.com/2076-3921/9/7/569
dc.description.versionPublisher's version
dc.format.extent17 pages
dc.identifier.citationBenade, J., et al. 2020. The impact of sugar-sweetened beverage consumption on the liver : a proteomics-based analysis. Antioxidants, 9(7):569, doi:10.3390/antiox9070569
dc.identifier.issn2076-3921 (online)
dc.identifier.otherdoi:10.3390/antiox9070569
dc.identifier.urihttp://hdl.handle.net/10019.1/122998
dc.language.isoen_ZAen_ZA
dc.publisherMDPI
dc.rights.holderAuthors retain copyright
dc.subjectSugar-sweetened beveragesen_ZA
dc.subjectMetabolic syndrome
dc.subjectType 2 diabetes mellitus
dc.titleThe impact of sugar-sweetened beverage consumption on the liver : a proteomics-based analysisen_ZA
dc.typeArticleen_ZA
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