Willingness to take multidrug-resistant tuberculosis (MDR-TB) preventive therapy among adult and adolescent household contacts of MDR-TB index cases : an international multisite cross-sectional study

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dc.contributor.authorSuryavanshi, Nishien_ZA
dc.contributor.authorMurrill, Matthewen_ZA
dc.contributor.authorGupta, Amitaen_ZA
dc.contributor.authorHughes, Michaelen_ZA
dc.contributor.authorHesseling, Annekeen_ZA
dc.contributor.authorKim, Soyeonen_ZA
dc.contributor.authorNaini, Lindaen_ZA
dc.contributor.authorJones, Lynneen_ZA
dc.contributor.authorSmith, Betsyen_ZA
dc.contributor.authorGupte, Nikhilen_ZA
dc.contributor.authorDawson, Rodneyen_ZA
dc.contributor.authorMave, Vidyaen_ZA
dc.contributor.authorMeshram, Sushanten_ZA
dc.contributor.authorMendoza-Ticona, Albertoen_ZA
dc.contributor.authorSanchez, Jorgeen_ZA
dc.contributor.authorKumarasamy, Nagalingeswaranen_ZA
dc.contributor.authorComins, Kylaen_ZA
dc.contributor.authorConradie, Francescaen_ZA
dc.contributor.authorShenje, Justinen_ZA
dc.contributor.authorFontain, Sandy Neretteen_ZA
dc.contributor.authorGarcia-Prats, Anthonyen_ZA
dc.contributor.authorAsmelash, Aidaen_ZA
dc.contributor.authorNedsuwan, Supalerten_ZA
dc.contributor.authorMohapi, Leratoen_ZA
dc.contributor.authorLalloo, Umeshen_ZA
dc.contributor.authorFerreira, Ana Cristina Garciaen_ZA
dc.contributor.authorOkeyo, Elishaen_ZA
dc.contributor.authorSwindells, Susanen_ZA
dc.contributor.authorChurchyard, Gavinen_ZA
dc.contributor.authorShah, N. Saritaen_ZA
dc.date.accessioned2022-06-07T13:28:02Zen_ZA
dc.date.available2022-06-07T13:28:02Zen_ZA
dc.date.issued2020-02en_ZA
dc.descriptionCITATION: Suryavanshi, N. et al. 2020. Willingness to Take Multidrug-resistant Tuberculosis (MDR-TB) Preventive Therapy Among Adult and Adolescent Household Contacts of MDR-TB Index Cases: An International Multisite Cross-sectional Study. Clinical Infectious Diseases, 70(3): 436–445. doi:10.1093/cid/ciz254en_ZA
dc.descriptionThe original publication is available at https://academic.oup.com/cid/en_ZA
dc.description.abstractBackground. Household contacts (HHCs) of individuals with multidrug-resistant tuberculosis (MDR-TB) are at high risk of infection and subsequent disease. There is limited evidence on the willingness of MDR-TB HHCs to take MDR-TB preventive therapy (MDR TPT) to decrease their risk of TB disease. Methods. In this cross-sectional study of HHCs of MDR-TB and rifampicin-resistant tuberculosis (RR-TB) index cases from 16 clinical research sites in 8 countries, enrollees were interviewed to assess willingness to take a hypothetical, newly developed MDR TPT if offered. To identify factors associated with willingness to take MDR TPT, a marginal logistic model was fitted using generalized estimating equations to account for household-level clustering. Results. From 278 MDR-TB/RR-TB index case households, 743 HHCs were enrolled; the median age of HHCs was 33 (interquartile range, 22-49) years, and 62% were women. HHC willingness to take hypothetical MDR TPT was high (79%) and remained high even with the potential for mild side effects (70%). Increased willingness was significantly associated with current employment or schooling (adjusted odds ratio [aOR], 1.83 [95% confidence interval {CI}, 1.07-3.13]), appropriate TB-related knowledge (aOR, 2.22 [95% CI, 1.23-3.99]), confidence in taking MDR TPT (aOR, 7.16 [95% CI, 3.33-15.42]), and being comfortable telling others about taking MDR TPT (aOR, 2.29 [95% CI, 1.29-4.06]). Conclusions. The high percentage of HHCs of MDR-TB/RR-TB index cases willing to take hypothetical MDR TPT provides important evidence for the potential uptake of effective MDR TPT when implemented. Identified HHC-level variables associated with willingness may inform education and counseling efforts to increase HHC confidence in and uptake of MDR TPT.en_ZA
dc.description.urihttps://academic.oup.com/cid/article/70/3/436/5421246?login=trueen_ZA
dc.description.versionPublishers versionen_ZA
dc.format.extent10 pagesen_ZA
dc.identifier.citationSuryavanshi, N. et al. 2020. Willingness to Take Multidrug-resistant Tuberculosis (MDR-TB) Preventive Therapy Among Adult and Adolescent Household Contacts of MDR-TB Index Cases: An International Multisite Cross-sectional Study. Clinical Infectious Diseases, 70(3): 436–445. doi:10.1093/cid/ciz254en_ZA
dc.identifier.issn1537-6591 (online)en_ZA
dc.identifier.issn1058-4838 (print)en_ZA
dc.identifier.otherdoi:10.1093/cid/ciz254en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/125337en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherOxford University Pressen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectMultidrug-resistant tuberculosisen_ZA
dc.subjectTuberculosis -- Preventionen_ZA
dc.subjectDrug resistanceen_ZA
dc.subjectProphylaxisen_ZA
dc.subjectPreventive therapyen_ZA
dc.titleWillingness to take multidrug-resistant tuberculosis (MDR-TB) preventive therapy among adult and adolescent household contacts of MDR-TB index cases : an international multisite cross-sectional studyen_ZA
dc.typeArticleen_ZA
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