Dynamics of respiratory gas exchange during exercise after correction of congenital heart disease

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dc.contributor.authorReybrouck T.
dc.contributor.authorMertens L.
dc.contributor.authorKalis N.
dc.contributor.authorWeymans M.
dc.contributor.authorDumoulin M.
dc.contributor.authorDaenen W.
dc.contributor.authorGewillig M.
dc.date.accessioned2011-05-15T16:16:50Z
dc.date.available2011-05-15T16:16:50Z
dc.date.issued1996
dc.description.abstractIn pediatric exercise testing, conventional measures of aerobic exercise function such as maximal O2 uptake or the ventilatory anaerobic threshold (VAT) use only one value for the assessment of exercise capacity. We studied a more comprehensive approach to evaluate aerobic exercise function by analyzing the steepness of the slope of CO2 production (V̇CO2) vs. V̇O2 above the VAT (S3). This was calculated in 32 patients operated on for congenital heart disease [16 for transposition of the great arteries (TGA) and 16 for tetralogy of Fallot (TF)] and was compared with 16 age-matched controls (nl). The results show that the reproducibility of this new assessment method was excellent (coefficient of variation for S3: 8.6%). S3 was significantly steeper (P < 0.05) in the patients (1.31 ± 0.22 for TGA and 1.28 ± 0.16 for TF) compared with the nl (1.10 ± 0.22). Also, the difference between S3 and the slope of V̇CO2 vs. V̇O2 below the VAT was significantly higher in the patients (0.37 ± 0.22 for TGA and 0.31 ± 0.10 for TF) than in controls (0.22 ± 0.06). The steeper slopes were associated with lower than normal values for VAT and O2 during exercise. It is concluded that the analysis of the steepness of the slope of CO2 is a sensitive, reproducible, and objective approach to evaluate the integrative cardiopulmonary response to exercise. It complements the assessment of a subnormal VAT by reflecting the extent of anaerobic metabolism.
dc.description.versionArticle
dc.identifier.citationJournal of Applied Physiology
dc.identifier.citation80
dc.identifier.citation2
dc.identifier.issn87507587
dc.identifier.urihttp://hdl.handle.net/10019.1/13954
dc.subjectcarbon dioxide
dc.subjectarticle
dc.subjectchild
dc.subjectclinical article
dc.subjectcongenital heart disease
dc.subjectexercise test
dc.subjectfallot tetralogy
dc.subjectfemale
dc.subjectgas exchange
dc.subjectgreat vessels transposition
dc.subjecthuman
dc.subjectlung gas exchange
dc.subjectmale
dc.subjectmuscle exercise
dc.subjectoxygen consumption
dc.subjectpriority journal
dc.subjectAerobiosis
dc.subjectAlgorithms
dc.subjectCarbon Dioxide
dc.subjectChild
dc.subjectExercise
dc.subjectExercise Test
dc.subjectFemale
dc.subjectHeart Defects, Congenital
dc.subjectHumans
dc.subjectMale
dc.subjectOxygen Consumption
dc.subjectPulmonary Gas Exchange
dc.subjectTetralogy of Fallot
dc.subjectTransposition of Great Vessels
dc.titleDynamics of respiratory gas exchange during exercise after correction of congenital heart disease
dc.typeArticle
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