HIV treatment as prevention : optimising the impact of expanded HIV treatment programmes

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dc.contributor.authorDelva, Wim
dc.contributor.authorEaton, Jeffrey W.
dc.contributor.authorMeng, Fei
dc.contributor.authorFraser, Christophe
dc.contributor.authorWhite, Richard G.
dc.contributor.authorVickerman, Peter
dc.contributor.authorBoily, Marie-Claude
dc.contributor.authorHallett, Timothy B.
dc.date.accessioned2012-08-06T10:58:24Z
dc.date.available2012-08-06T10:58:24Z
dc.date.issued2012-07
dc.descriptionThe original publication is available at http://www.plosmedicine.orgen_ZA
dc.description.abstractUntil now, decisions about how to allocate ART have largely been based on maximising the therapeutic benefit of ART for patients. Since the results of the HPTN 052 study showed efficacy of antiretroviral therapy (ART) in preventing HIV transmission, there has been increased interest in the benefits of ART not only as treatment, but also in prevention. Resources for expanding ART in the short term may be limited, so the question is how to generate the most prevention benefit from realistic potential increases in the availability of ART. Although not a formal systematic review, here we review different ways in which access to ART could be expanded by prioritising access to particular groups based on clinical or behavioural factors. For each group we consider (i) the clinical and epidemiological benefits, (ii) the potential feasibility, acceptability, and equity, and (iii) the affordability and cost-effectiveness of prioritising ART access for that group. In re-evaluating the allocation of ART in light of the new data about ART preventing transmission, the goal should be to create policies that maximise epidemiological and clinical benefit while still being feasible, affordable, acceptable, and equitable.en_ZA
dc.description.versionPublishers' Versionen_ZA
dc.format.extent12 p. : ill.
dc.identifier.citationDelva, W. et al. 2012. HIV treatment as prevention: optimising the impact of expanded HIV treatment orogrammes. PLoS Med, 9(7), e1001258, doi:10.1371/journal.pmed.1001258.en_ZA
dc.identifier.issn1549-1676 (online)
dc.identifier.issn1549-1277 (print)
dc.identifier.otherdoi:10.1371/journal.pmed.1001258
dc.identifier.urihttp://hdl.handle.net/10019.1/22019
dc.language.isoen_ZAen_ZA
dc.publisherPublic Library of Science (PLOS)en_ZA
dc.rights.holderAuthors retain the copyrighten_ZA
dc.subjectHIV infections -- Treatmenten_ZA
dc.subjectHIV infections -- Preventionen_ZA
dc.subjectHIV treatment programmesen_ZA
dc.titleHIV treatment as prevention : optimising the impact of expanded HIV treatment programmesen_ZA
dc.typeArticleen_ZA
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