Effect of sperm preincubation time on GIFT pregnancy outcome

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dc.contributor.authorCoetzee K.
dc.contributor.authorStander F.S.H.
dc.contributor.authorWindt M.-L.
dc.contributor.authorErasmus E.
dc.contributor.authorSmith K.
dc.contributor.authorKruger T.F.
dc.contributor.authorVan Der Merwe J.P.
dc.contributor.authorLombard C.J.
dc.date.accessioned2011-05-15T16:15:34Z
dc.date.available2011-05-15T16:15:34Z
dc.date.issued1997
dc.description.abstractThis investigation was conducted to evaluate the effect of human sperm preincubation time on the pregnancy outcome in gamete intrafallopian tube transfers. This was determined in a retrospective study on gamete intrafallopian transfer patients (ideopathic infertility) using logistic regression with the covariates, preincubation time (≤60 and >60 min) and age (≤35 and >35 years). The study included 485 consecutive gamete intrafallopian transfer cycles in which 3 metaphase II oocytes were transferred. Pregnancy outcome was evaluated by βhCG levels on days 12 and 16 and was confirmed by the presence of a fetal heart 8 weeks after the procedure by means of sonography. The wife's age and sperm preincubation time were significant covariates in the prediction of ongoing pregnancy. The odds ratio for age (≤35 years) was 2.2 in the prediction of ongoing pregnancy, while the age-adjusted odds ratios for preincubation time (≤60 min) was 1.9. There was a critical relationship between sperm preincubation time and GIFT success, which confirms the effect of the wife's age on pregnancy. Close coordination is of importance between the clinical scientist and the physician to restrict the preincubation time to 1 h. The sperm preincubation time is a significant factor that has to be considered in the prediction of ongoing pregnancy in GIFT patients.
dc.description.versionArticle
dc.identifier.citationArchives of Andrology
dc.identifier.citation38
dc.identifier.citation2
dc.identifier.issn01485016
dc.identifier.urihttp://hdl.handle.net/10019.1/13394
dc.subjectadult
dc.subjectage
dc.subjectarticle
dc.subjectfemale
dc.subjectfertilization in vitro
dc.subjectgamete intrafallopian transfer
dc.subjecthuman
dc.subjecthuman cell
dc.subjectinfertility
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectovulation induction
dc.subjectprediction
dc.subjectpregnancy rate
dc.subjectpriority journal
dc.subjectspermatozoon capacitation
dc.subjectspermatozoon maturation
dc.subjectAdult
dc.subjectFemale
dc.subjectGamete Intrafallopian Transfer
dc.subjectHumans
dc.subjectMale
dc.subjectPregnancy
dc.subjectRetrospective Studies
dc.subjectSpermatozoa
dc.subjectTime Factors
dc.titleEffect of sperm preincubation time on GIFT pregnancy outcome
dc.typeArticle
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