Predictive value of normal sperm morphology in intrauterine insemination (IUI) : a structured literature review

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dc.contributor.advisorKruger, T. F.
dc.contributor.authorVan Waart, J. (Johannes)
dc.contributor.otherStellenbosch University. Faculty of Medicine & Health Sciences . Dept. of Obstetrics & Gynaecology.en_ZA
dc.date.accessioned2012-08-27T11:34:59Z
dc.date.available2012-08-27T11:34:59Z
dc.date.issued2001-12
dc.descriptionThesis (MMed)--Stellenbosch University, 2001.en_ZA
dc.description.abstractENGLISH ABSTRACT: The aim of the study was to conduct a structured review of the literature published on the use of normal sperm morphology, as an indicator of male fertility potential in intrauterine insemination (M) programs. Published literature in which normal sperm morphology was used to predict pregnancy outcome in lUI during the period 1984 - 1998 was reviewed. Four hundred and twenty one articles were identified. Eighteen provided data that could be tabulated and analyzed. Eight of the analyzed studies provided sufficient data for statistical analysis. Six studies used the Tygerberg strict criteria and two the WHO guidelines (1987, 1992). A meta-analysis of the six studies in the strict morphology group yielded a risk difference (RD) between the pregnancy rates achieved in the patients below and above the 4% strict criteria threshold of -0.07 (95% CI: -0.11 to -0.03; p< 0.001). WHO criteria group (1987,1992) had insufficient data to be analysed. Meta-analysis showed a significant improvement in pregnancy rate above 4% threshold for strict criteria. Accurate evaluation of normal sperm morphology results should be an integral part of evaluating the male factor.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Die doel van die studie was om 'n gestruktureerde literatuuroorsig van die gepubliseerde data oor normale sperm morfologie uit te voer om vas te stelof dit enige waarde het as voorspeller van manlike fertiliteitspotensiaal in intra uteriene inseminasie (lUI) programme. Gepubliseerde literatuur waar normale sperm morfologie gebruik IS om swangerskapsuitkoms te voorspel met IUI in die tydperk 1984 - 1998 is nagegaan. Vierhonderd een en twintig artikels is geïdentifiseer. Agtien het genoeg data gehad om te kan tabuleer en analiseer. Agt van die geanaliseerde studies het voldoende data gehad vir statistiese analise. Ses studies het die Tygerberg streng kriteria gebruik en twee die WGO (1987, 1992) riglyne. 'n Meta-analise van die ses studies in die streng kriteria groep het 'n risiko verskil tussen swangerskapstempo in pasiënte onder en bo die 4% streng kriteria afsnypunt, van -0,07 (95% betroubaarheidsindeks: -0.11 tot -0.03; p<O.OOl) getoon. Die WGO kriteria (1987,1992) groep het onvoldoende data gehad om te kan analiseer. Meta-analise het 'n bekenisvolle verbetering in swangerskapuitkoms bo die 4% afsnypunt getoon vir die streng kriteria. Akkurate evaluasie van normale sperm morfologie resultate behoort 'n integrale deel te wees van die proses om die manlike faktor in infertilteitsbehandeling volledig te evalueer.af_ZA
dc.format.extent25 p.
dc.identifier.urihttp://hdl.handle.net/10019.1/52411
dc.language.isoen_ZAen_ZA
dc.publisherStellenbosch : Stellenbosch Universityen_ZA
dc.rights.holderStellenbosch Universityen_ZA
dc.subjectArtificial insemination, Humanen_ZA
dc.subjectSpermatozoa -- Motilityen_ZA
dc.subjectFertility, Humanen_ZA
dc.subjectDissertations -- Medicineen_ZA
dc.subjectTheses -- Medicineen_ZA
dc.subjectDissertations -- Obstetrics and gynaecologyen_ZA
dc.subjectTheses -- Obstetrics and gynaecologyen_ZA
dc.titlePredictive value of normal sperm morphology in intrauterine insemination (IUI) : a structured literature reviewen_ZA
dc.typeThesisen_ZA
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