Deposition and transport of linezolid mediated by a synthetic surfactant Synsurf® within a pressurized metered dose inhaler : a Calu-3 model

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dc.contributor.authorVan Rensburg, Lyneen_ZA
dc.contributor.authorVan Zyl, Johann M.en_ZA
dc.contributor.authorSmith, Johanen_ZA
dc.date.accessioned2019-09-16T09:30:36Z
dc.date.available2019-09-16T09:30:36Z
dc.date.issued2018
dc.descriptionCITATION: Van Rensburg, L., Van Zyl, J. M. & Smith, J. 2018. Deposition and transport of linezolid mediated by a synthetic surfactant Synsurf® within a pressurized metered dose inhaler : a Calu-3 model. Drug Design, Development and Therapy, 12-1107-1118, doi:10.2147/DDDT.S147035.
dc.descriptionThe original publication is available at https://www.dovepress.com
dc.description.abstractBackground: Previous studies in our laboratory demonstrated that a synthetic peptide containing lung surfactant enhances the permeability of chemical compounds through bronchial epithelium. The purpose of this study was to test two formulations of Synsurf® combined with linezolid as respirable compounds using a pressurized metered dose inhaler (pMDI). Methods: Aerosolization efficiency of the surfactant-drug microparticles onto Calu-3 monolayers as an air interface culture was analyzed using a Next Generation Impactor™. Results: The delivered particles and drug dose showed a high dependency from the preparation that was aerosolized. Scanning electron microscopy imaging allowed for visualization of the deposited particles, establishing them as liposomal-type structures (diameter 500 nm to 2 µm) with filamentous features. Conclusion: The different surfactant drug combinations allow for an evaluation of the significance of the experimental model system, as well as assessment of the formulations providing a possible noninvasive, site-specific, delivery model via pMDI.en_ZA
dc.description.urihttps://www.dovepress.com/deposition-and-transport-of-linezolid-mediated-by-a-synthetic-surfacta-peer-reviewed-article-DDDT#
dc.description.versionPublisher's version
dc.format.extent12 pagesen_ZA
dc.identifier.citationVan Rensburg, L., Van Zyl, J. M. & Smith, J. 2018. Deposition and transport of linezolid mediated by a synthetic surfactant Synsurf® within a pressurized metered dose inhaler : a Calu-3 model. Drug Design, Development and Therapy, 12-1107-1118, doi:10.2147/DDDT.S147035
dc.identifier.issn1177-8881 (online)
dc.identifier.otherdoi:10.2147/DDDT.S147035
dc.identifier.urihttp://hdl.handle.net/10019.1/106476
dc.language.isoen_ZAen_ZA
dc.publisherDove Medical Pressen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectDelivery vehicleen_ZA
dc.subjectPulmonary surfactanten_ZA
dc.subjectAerosolsen_ZA
dc.titleDeposition and transport of linezolid mediated by a synthetic surfactant Synsurf® within a pressurized metered dose inhaler : a Calu-3 modelen_ZA
dc.typeArticleen_ZA
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