A statistical shape modelling approach towards the design of a temporomandibular joint implant

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dc.contributor.advisorVan der Merwe, Johanen_ZA
dc.contributor.advisorBecker, Thorsten Hermann en_ZA
dc.contributor.authorLubbe, Inge en_ZA
dc.contributor.otherStellenbosch University. Faculty of Engineering. Dept. of Mechanical and Mechatronic Engineering.en_ZA
dc.date.accessioned2023-11-22T17:05:31Zen_ZA
dc.date.accessioned2024-01-08T21:36:22Zen_ZA
dc.date.available2023-11-22T17:05:31Zen_ZA
dc.date.available2024-01-08T21:36:22Zen_ZA
dc.date.issued2023-11en_ZA
dc.descriptionThesis (MEng)--Stellenbosch University, 2023.en_ZA
dc.description.abstractENGLISH ABSTRACT: The anatomic temporomandibular joint (TMJ) functions as a synovial-joint system whose bilateral bony structures includes the temporal bone and mandible. Articulation is facilitated by the articular disc (within the joint capsule) and ligamentous structures while being supported by the masticatory system. Temporomandibular joint (TMJ) implant design involves the collaborative application of anatomic knowledge and engineering concepts. Medical device design research and development specific to TMJ implant systems is seen to mainly focus on implications of existing systems within implant design history, biomaterial implantology research and clinical success rates. Therefore, in this work a TMJ implant design process was defined from shared attributes in existing TMJ implant systems where the boundaries of development form a sequence of design stages and consistent design features. The developed TMJ implant design process was then implemented in the initial development of a mandibular component design. Anatomic modelling was identified as an important part of the modelling framework to investigate as it can be used to define aspects such as the overall geometric design specifications, geometric design parameters and features within the design formation stage, and validation procedures. A cephalometric analysis of measurements associated with design and surgical navigation was performed followed by the development and implementation of validated statistical shape models to evaluate shape variation. The investigated dataset consisted of 80 subjects (40 males, 52.1 ± 5.9 years; 40 females, 56.7 ± 9.4 years). The data quality and normality were confirmed with a series of inter- and intra-examiner error analyses using an intraclass correlation coefficient (ICC) and Quantile-Quantile (Q-Q) plots, respectively. Size-related anatomic variation (bilateral and sex dimorphism) and anatomic measurement parameter correlations were examined in a cephalometric analysis. Significant sex-related differences (parameter correlation). The mandibular component implant design was formulated using the cephalometric measurements as proposed parameter ranges. In addition, the developed statistical shape models (SSMs) were used to evaluate the level of customisation required in the design implementing a cluster analysis. An implant library size of six implants was determined to sufficiently support the population where the implant-mandible fit was used as the evaluation metric. The female and male implant designs resulted in a mean root means square (RMS) error of 0.71 ± 0.13 mm and 0.67 ± 0.24 mm, respectively. These results were determined to be within the allowable bone modification and screw capability limits (clinically acceptable).en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Die anatomiese temporomandibulêre gewrig (TMJ) funksioneer soos ‘n sinovialegewrig sisteem met bilaterale benige structure wat die temporale been en mandible insluit. Artikulasie vord gefasiliteer deur die artikulere skyf (binne die gewrig kapsel) en die ligament terwyl dit ondersteun word deur die kou spiere. Temporomandibulêre gewrig (TMJ) inplantaat ontwerp behels die gesamentlike toepassing van anatomiese kennis en ingenieurs konsepte. Narvorsing en ontwikkeling van mediese toestelle spesifiek vir TMJ-inplantingstelsels fokus hoofsaaklik op die implikasies van bestaande stelsels binne die geskiedenis van inplantings ontwerp, biomateriaal inplantings narvorsing en kliniese sukses koerse. ‘n TMJ-inplantings ontwerp proses is in hierdie studie gedefinieer uit gedeelde eienskappe in bestaande TMJ-inplantingstelsels waar die grense van ontwikkeling ‘n reeks ontwerpstadia en konsekwente ontwerp kenmerke vorm. Die ontwikkelde TMJ-inplantings ontwerp proses is in die aanvanklike ontwikkeling van 'n mandibulêre komponentontwerp geïmplementeer. Anatomiese modellering is ‘n belangrike deel van die modelleringsraamwerk waar die volgende aspekte soos die algehele geometriese ontwerp spesifikasies, geometriese parameters en ontwerpkenmerke binne die ontwerp vorming stadium, en valideringsprosedures. ‘n Kefalometriese analise van metings wat verband hou met ontwerp en chirurgiese navigasie is uitgevoer, gevolg deur die ontwikkeling en implementering van gevalideerde statistiese vormmodelle om vormvariasie te evalueer. Die ondersoekte data basis bestoon uit 80 individue (40 manlik, 52.1 ± 5.9 jare; 40 vroulik, 56.7 ± 9.4 jare). Die data kwaliteit and normaliteit was bevestig met ‘n reeks inter- en intra-ondersoeker foutanalise deur bepaling van binnegroupkoëffisiënt (ICC) en Kwantiel-Kwantiel (Q-Q) stipping onderskeidelik. Grootte verwante anatomiese variasie (bilaterale en geslagsdimorfisme) en anatomiese metings en parameter korrelasies is in 'n kefalometriese analise ondersoek. Beduidende geslagsverwante verskille (p<0.001) is in die meerderheid van die parameters uitgesluit, met uitsondering van die kondilêre nek hoogte (16.93 ± 3.17 mm), agter nek hoek (66.93 ± 5.89°), en binneste nek hoek (10.88 ± 1.81°). Dit is vasgestel dat die mandibel geen bilaterale beduidende verskille het nie, wat daarop dui dat die TMJ-inplantings ontwerp nie onafhanklik vir elke kant gedefinieer hoef te word nie. Die statistiese toetse uitgevoer sluit in: gepaarde T-toets, Fisher F-toets, onafhanklike T-toets, en Pearson korrelasiekoëffisiënt. Die mandibulêre komponentontwerp gebruik die kefalometriese metings om voorgestelde parameter reekse te geformuleer. Daarbenewens is die ontwikkelde statistiese vorm modelle (SSM) gebruik om die vlak van aanpassing in ontwerp te ondesoek waar ‘n trosanalise gebruik word. ‘n Inplantaatbiblioteek van ses inplantate is bepaal om die populasie waar die inplanting- mandibulêre passing as die evalueringsmetriek geïmplementeer is, voldoende te ondersteun. Die vroulike en manlike inplantaatontwerpe het 'n gemiddelde wortelgemiddelde kwadraat (RMS) fout van onderskeidelik 0.71 ± 0.13 mm en 0.67 ± 0.24 mm onderskeidelik gelei. Die resultate is binne die toelaatbare beenmodifikasie- en skroefvermoëlimiete (klinies aanvaarbaar) vasgestel.af_ZA
dc.description.versionMastersen_ZA
dc.format.extentxii, 117 pages : illustrationsen_ZA
dc.identifier.urihttps://scholar.sun.ac.za/handle/10019.1/129078en_ZA
dc.language.isoen_ZAen_ZA
dc.language.isoen_ZAen_ZA
dc.publisherStellenbosch : Stellenbosch Universityen_ZA
dc.rights.holderStellenbosch Universityen_ZA
dc.subject.lcshTemporomandibular jointen_ZA
dc.subject.lcshStatistical shape modelsen_ZA
dc.subject.lcshCephalometryen_ZA
dc.subject.lcshHuman anatomy -- Modelsen_ZA
dc.subject.lcshImplant designen_ZA
dc.titleA statistical shape modelling approach towards the design of a temporomandibular joint implanten_ZA
dc.typeThesisen_ZA
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