Prognostic value of day 14 blast percentage and the absolute blast index in bone marrow of children with acute lymphoblastic leukemia
Date
2001
Authors
Visser J.H.
Wessels G.
Hesseling P.B.
Mmed I.L.
Oberholster E.
Mansvelt E.P.G.
Journal Title
Journal ISSN
Volume Title
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Abstract
The product of the percentage blasts on the bone marrow aspirate (BMA) and the biopsy cellularity has been tarmed the "absolute blast index aspirate" (ABI-aspirate) and is used to measure disease response on day 7 of induction therapy. The authors compared the event-free survival (EFS) in high-risk and standard-risk patients as identified by the ABI-aspirate and the BMA percentage blasts on day 14 of induction therapy. Both indices identified high-risk cases. EFS of patients categorized as high-risk by these 2 methods and the high-risk criteria used by the authors' service (WCC of > 20 × 109/L, age < 2 and > 8 years and a peripheral blood blast count of > 1.0 × 109/L on day 8 of induction) did not differ. There was concordance between patients identified as high risk by all 3 methods. The results confirmed the prognostic value of the ABI-aspirate and the BMA percentage blasts on day 14 of induction therapy, but these methods were not superior to the high-risk criteria currently in use.
Description
Keywords
acute lymphoblastic leukemia, adolescent, article, blast cell, bone marrow biopsy, bone marrow examination, cancer survival, child, female, high risk patient, human, infant, male, prognosis, 6-Mercaptopurine, Adolescent, Antineoplastic Combined Chemotherapy Protocols, Asparaginase, Biopsy, Needle, Blast Crisis, Bone Marrow, Child, Child, Preschool, Cyclophosphamide, Cytarabine, Daunorubicin, Disease-Free Survival, Ethnic Groups, Female, Follow-Up Studies, Humans, Infant, Leukemia, Lymphocytic, Acute, Male, Methotrexate, Predictive Value of Tests, Prednisone, Prognosis, Recurrence, Risk Assessment, South Africa, Survival Rate, Time Factors, Vincristine
Citation
Pediatric Hematology and Oncology
18
3
18
3