Pleural tuberculosis in patients with early HIV infection is associated with increased TNF-alpha expression and necrosis in granulomas

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dc.contributor.authorBezuidenhout, Juanitaen_ZA
dc.contributor.authorRoberts, Terien_ZA
dc.contributor.authorMuller, Lieselen_ZA
dc.contributor.authorVan Helden, Paulen_ZA
dc.contributor.authorWalzl, Gerharden_ZA
dc.date.accessioned2011-05-15T16:17:44Z
dc.date.available2011-05-15T16:17:44Z
dc.date.issued2009-01-19
dc.descriptionCITATION: Bezuidenhout, J. et al. 2009. Pleural tuberculosis in patients with early HIV infection is associated with increased TNF-alpha expression and necrosis in granulomas. PLoS ONE, 4(1): e4228, doi:10.1371/journal.pone.0004228.
dc.descriptionThe original publication is available at http://journals.plos.org/plosone
dc.description.abstractAlthough granulomas may be an essential host response against persistent antigens, they are also associated with immunopathology. We investigated whether HIV co-infection affects histopathological appearance and cytokine profiles of pleural granulomas in patients with active pleural tuberculosis (TB). Granulomas were investigated in pleural biopsies from HIV positive and negative TB pleuritis patients. Granulomas were characterised as necrotic or non-necrotic, graded histologically and investigated for the mRNA expression of IL-12, IFN-γ, TNF-α and IL-4 by in situ hybridisation. In all TB patients a mixed Th1/Th2 profile was noted. Necrotic granulomas were more evident in HIV positive patients with a clear association between TNF-α and necrosis. This study demonstrates immune dysregulation which may include TNF-α-mediated immunopathology at the site of disease in HIV infected pleural TB patients. © 2009 Bezuidenhout et al.
dc.description.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004228
dc.description.versionArticle
dc.description.versionPublisher's version
dc.format.extent8 pages
dc.identifier.citationBezuidenhout, J. et al. 2009. Pleural tuberculosis in patients with early HIV infection is associated with increased TNF-alpha expression and necrosis in granulomas. PLoS ONE, 4(1): e4228, doi:10.1371/journal.pone.0004228.
dc.identifier.issn1932-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0004228
dc.identifier.urihttp://hdl.handle.net/10019.1/14351
dc.language.isoen
dc.publisherPublic Library of Science
dc.rights.holderAuthors retain copyright
dc.subjectTuberculosisen_ZA
dc.subjectHIV infectionse
dc.subjectGranulomaen_ZA
dc.titlePleural tuberculosis in patients with early HIV infection is associated with increased TNF-alpha expression and necrosis in granulomasen_ZA
dc.typeArticle
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