Past and present approaches to diagnosis of active pulmonary tuberculosis

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dc.contributor.authorNamuganga, Anna Ritahen_ZA
dc.contributor.authorChegou, Novel N.en_ZA
dc.contributor.authorMayanja-Kizza, Harrieten_ZA
dc.date.accessioned2022-01-03T08:54:32Z
dc.date.available2022-01-03T08:54:32Z
dc.date.issued2021-09-23
dc.descriptionCITATION: Namuganga, A. R., Chegou, N. N. & Mayanja-Kizza, H. 2021. Past and present approaches to diagnosis of active pulmonary tuberculosis. Frontiers in Medicine, 8:709793, doi:10.3389/fmed.2021.709793.
dc.descriptionThe original publication is available at https://www.frontiersin.org
dc.description.abstractENGLISH ABSTRACT: Tuberculosis disease continues to contribute to the mortality burden globally. Due to the several shortcomings of the available diagnostic methods, tuberculosis disease continues to spread. The difficulty to obtain sputum among the very ill patients and the children also affects the quick diagnosis of tuberculosis disease. These challenges warrant investigating different sample types that can provide results in a short time. Highlighted in this review are the approved pulmonary tuberculosis diagnostic methods and ongoing research to improve its diagnosis. We used the PRISMA guidelines for systematic reviews to search for studies that met the selection criteria for this review. In this review we found out that enormous biosignature research is ongoing to identify host biomarkers that can be used as predictors of active PTB disease. On top of this, more research was also being done to improve already existing diagnostic tests. Host markers required more optimization for use in different settings given their varying sensitivity and specificity in PTB endemic and non-endemic settings.en_ZA
dc.description.versionPublisher's version
dc.format.extent12 pagesen_ZA
dc.identifier.citationNamuganga, A. R., Chegou, N. N. & Mayanja-Kizza, H. 2021. Past and present approaches to diagnosis of active pulmonary tuberculosis. Frontiers in Medicine, 8:709793, doi:10.3389/fmed.2021.709793.
dc.identifier.issn2296-858X (online)
dc.identifier.otherdoi:10.3389/fmed.2021.709793
dc.identifier.urihttp://hdl.handle.net/10019.1/124028
dc.language.isoen_ZAen_ZA
dc.publisherFrontiersen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectTuberculosisen_ZA
dc.subjectTuberculosis -- Diagnosisen_ZA
dc.subjectTuberculosis -- Preventionen_ZA
dc.subjectPulmonary tuberculosis -- Treatmenten_ZA
dc.titlePast and present approaches to diagnosis of active pulmonary tuberculosisen_ZA
dc.typeArticleen_ZA
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