Intrauterine insemination: A systematic review on determinants of success

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dc.contributor.authorDuran H.E.
dc.contributor.authorMorshedi M.
dc.contributor.authorKruger T.
dc.contributor.authorOehninger S.
dc.date.accessioned2011-05-15T16:16:35Z
dc.date.available2011-05-15T16:16:35Z
dc.date.issued2002
dc.description.abstractIntrauterine insemination (IUI) is a frequently indicated therapeutic modality in infertility. Here, a systematic review of the literature was performed to examine the current status of clinical and laboratory methodologies used in IUI and the impact of female and male factors on pregnancy success. Emphasis was centred in questioning the following: (i) the value of IUI against timed intercourse; (ii) IUI application with or without controlled ovarian hyperstimulation; (iii) timing and frequency of IUI; and (iv) impact of various parameters (male/female) on the prediction of pregnancy outcome. The odds of multiple pregnancy occurrence and its risk factors, as well as the cost-effectiveness of IUI treatment compared with more complex assisted reproductive technologies are discussed. A computerized literature search was performed including Medline and the Cochrane library, as well as a crossover search from retrieved papers. It is concluded that although IUI is a successful contemporary treatment for appropriately selected cases of female and/or male infertility, further research is needed through well-designed studies to improve the methodologies currently utilized. Importantly, the clinical management of the infertile couple should be performed in an expedited manner taking into consideration the age of the woman, the presence of multifactorial infertility and cost-effectiveness of the available treatment alternatives.
dc.description.versionArticle
dc.identifier.citationHuman Reproduction Update
dc.identifier.citation8
dc.identifier.citation4
dc.identifier.issn13554786
dc.identifier.other10.1093/humupd/8.4.373
dc.identifier.urihttp://hdl.handle.net/10019.1/13851
dc.subjectage
dc.subjectarticle
dc.subjectclinical research
dc.subjectCochrane Library
dc.subjectcontrolled study
dc.subjectcost effectiveness analysis
dc.subjectfemale infertility
dc.subjecthuman
dc.subjectintermethod comparison
dc.subjectintrauterine insemination
dc.subjectmale infertility
dc.subjectmedical literature
dc.subjectMEDLINE
dc.subjectmethodology
dc.subjectmultiple pregnancy
dc.subjectovary
dc.subjectprediction
dc.subjectpregnancy
dc.subjectpriority journal
dc.subjectrisk factor
dc.subjectsexual intercourse
dc.subjecttreatment indication
dc.subjecttreatment outcome
dc.subjectartificial insemination
dc.subjectfemale
dc.subjectinfertility therapy
dc.subjectmale
dc.subjectphysiology
dc.subjectpregnancy outcome
dc.subjectuterus
dc.subjectFemale
dc.subjectHuman
dc.subjectInsemination, Artificial
dc.subjectMale
dc.subjectPregnancy
dc.subjectPregnancy Outcome
dc.subjectPregnancy, Multiple
dc.subjectReproductive Techniques, Assisted
dc.subjectUterus
dc.subjectHumans
dc.titleIntrauterine insemination: A systematic review on determinants of success
dc.typeArticle
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