Antibacterial properties of tough and strong electrospun PMMA/PEO fiber mats filled with lanasol : a naturally occurring brominated substance

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dc.contributor.authorAndersson, Richard L.en_ZA
dc.contributor.authorMartínez-Abad, Antonioen_ZA
dc.contributor.authorLagaron, Jose M.en_ZA
dc.contributor.authorGedde, Ulf W.en_ZA
dc.contributor.authorMallon, Peter E.en_ZA
dc.contributor.authorOlsson, Richard T.en_ZA
dc.contributor.authorHedenqvist, Mikael S.en_ZA
dc.date.accessioned2016-01-14T06:42:28Z
dc.date.available2016-01-14T06:42:28Z
dc.date.issued2014-09-09
dc.descriptionPlease cite as follows: Andersson, R. L. et al. 2014. Antibacterial properties of tough and strong electrospun PMMA/PEO fiber mats filled with lanasol: a naturally occurring brominated substance. International Journal of Molecular Sciences, 15(9):15912-15923, doi:10.3390/ijms150915912.en_ZA
dc.descriptionThe original publication is available at http://www.mdpi.com/journal/ijmsen_ZA
dc.description.abstractA new type of antimicrobial, biocompatible and toughness enhanced ultra-thin fiber mats for biomedical applications is presented. The tough and porous fiber mats were obtained by electrospinning solution-blended poly (methyl methacrylate) (PMMA) and polyethylene oxide (PEO), filled with up to 25 wt % of Lanasol—a naturally occurring brominated cyclic compound that can be extracted from red sea algae. Antibacterial effectiveness was tested following the industrial Standard JIS L 1902 and under agitated medium (ASTM E2149). Even at the lowest concentrations of Lanasol, 4 wt %, a significant bactericidal effect was seen with a 4-log (99.99%) reduction in bacterial viability against S. aureus, which is one of the leading causes of hospital-acquired (nosocomial) infections in the world. The mechanical fiber toughness was insignificantly altered up to the maximum Lanasol concentration tested, and was for all fiber mats orders of magnitudes higher than electrospun fibers based on solely PMMA. This antimicrobial fiber system, relying on a dissolved antimicrobial agent (demonstrated by X-ray diffraction and Infrared (IR)-spectroscopy) rather than a dispersed and “mixed-in” solid antibacterial particle phase, presents a new concept which opens the door to tougher, stronger and more ductile antimicrobial fibers.en_ZA
dc.description.urihttp://www.mdpi.com/1422-0067/15/9/15912
dc.description.versionPublisher's versionen_ZA
dc.format.extent12 pagesen_ZA
dc.identifier.citationAndersson, R. L. et al. 2014. Antibacterial properties of tough and strong electrospun PMMA/PEO fiber mats filled with lanasol: a naturally occurring brominated substance. International Journal of Molecular Sciences, 15(9):15912-15923, doi:10.3390/ijms150915912.
dc.identifier.issn1422-0067 (online)
dc.identifier.issn1661-6596 (print)
dc.identifier.otherdoi:10.3390/ijms150915912
dc.identifier.urihttp://hdl.handle.net/10019.1/98170
dc.language.isoen_ZAen_ZA
dc.publisherMDPI
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectElectrospinningen_ZA
dc.subjectLanasolen_ZA
dc.subjectNanofibersen_ZA
dc.subjectPolyethylene oxideen_ZA
dc.titleAntibacterial properties of tough and strong electrospun PMMA/PEO fiber mats filled with lanasol : a naturally occurring brominated substanceen_ZA
dc.typeArticleen_ZA
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