Transferrin C2 and Alzheimer's disease: Another piece of the puzzle found?

dc.contributor.authorVan Rensburg S.J.
dc.date.accessioned2011-05-15T16:17:21Z
dc.date.available2011-05-15T16:17:21Z
dc.date.issued1995
dc.description.abstractA significant increase in the occurrence of the transferrin C2 genetic subtype has been found in patients with Alzheimer's disease. This variant has previously been linked to diseases thought to be associated with free radical damage. We hypothesize that Alzheimer's disease is caused by free radical damage to membranes of endocytic vesicles due to defective binding of iron and aluminium by Tf C2. The aluminium binds to the membranes, creating pores, while the iron reacts with H2O2 and superoxide radicals produced by activated microglia (brain phagocytes), to produce hydroxyl radicals (oxidative toxins), which attack the fatty acids in the membranes through these pores. In order to treat the disease successfully, it would be necessary to alleviate the multiple deficiencies caused by these toxins by constantly providing the cells with antioxidants and other essential nutrients. In addition, a drug that would stimulate the regrowth of neurons is needed.
dc.description.versionShort Survey
dc.identifier.citationMedical Hypotheses
dc.identifier.citation44
dc.identifier.citation4
dc.identifier.issn03069877
dc.identifier.other10.1016/0306-9877(95)90178-7
dc.identifier.urihttp://hdl.handle.net/10019.1/14181
dc.subjectaluminum
dc.subjectfree radical
dc.subjecthydrogen peroxide
dc.subjectiron
dc.subjectsuperoxide
dc.subjecttransferrin
dc.subjecttransferrin c2
dc.subjectunclassified drug
dc.subjectalzheimer disease
dc.subjecthuman
dc.subjectmicroglia
dc.subjectpriority journal
dc.subjectshort survey
dc.subjectAluminum
dc.subjectAlzheimer Disease
dc.subjectEndocytosis
dc.subjectFree Radicals
dc.subjectHuman
dc.subjectHydroxyl Radical
dc.subjectImmune System
dc.subjectIron
dc.subjectLipid Peroxidation
dc.subjectMicroglia
dc.subjectModels, Biological
dc.subjectReceptors, Transferrin
dc.subjectSupport, Non-U.S. Gov't
dc.subjectTransferrin
dc.subjectVariation (Genetics)
dc.titleTransferrin C2 and Alzheimer's disease: Another piece of the puzzle found?
dc.typeShort Survey
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