The simultaneous determination of cerebrospinal fluid and plasma adenosine deaminase activity as a diagnostic aid in tuberculous meningitis

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dc.contributor.authorDonald, P. R.en_ZA
dc.contributor.authorMalan, Christinaen_ZA
dc.contributor.authorVan der Walt, Adrien_ZA
dc.contributor.authorSchoeman, J. F.en_ZA
dc.date.accessioned2011-03-18T14:59:39Z
dc.date.available2011-03-18T14:59:39Z
dc.date.issued1986-04
dc.descriptionCITATION: Donald, P.R., et al. 1986. The simultaneous determination of cerebrospinal fluid and plasma adenosine deaminase activity as a diagnostic aid in tuberculous meningitis. South African Medical Journal, 69(4), 505-507.en_ZA
dc.descriptionThe original publication is available at http://www.samj.org.zaen_ZA
dc.description.abstractThe simultaneous determination of cerebrospinal fluid (CSF) and plasma adenosine deaminase (ADA) activity was evaluated as a diagnostic aid in tuberculous meningitis (TBM). CSF and plasma ADA activity were determined in four groups of patients: (i) a 'no meningitis' group of 174 children investigated for possible meningitis, but found to be uninfected; (ii) an aseptic meningitis group of 40 children; (iii) a bacterial meningitis group of 31 children; and (iv) a TBM group of 27 patients (24 children and 3 adults). CSF ADA alone was determined in a further 23 children with aseptic meningitis, 19 with bacterial meningitis and 13 children and 7 adults with TBM. Both the CSF/plasma ADA ratio and the absolute CSF ADA activity were raised in TBM (mean values 0.24 and 12.61 U/l respectively) and bacterial meningitis (mean values 0.59 and 15.43 U/l respectively), but not in the aseptic meningitis group (mean values 0.06 and 2.00 U/l) or the 'no meningitis' group (mean values 0.04 and 1.51 U/l). Both values will distinguish TBM from aseptic meningitis, but do not appear to hold any marked advantages over conventional CSF criteria in the diagnosis of TBM.en_ZA
dc.description.versionPublisher’s version
dc.identifier.citationDonald, P.R., et al. 1986. The simultaneous determination of cerebrospinal fluid and plasma adenosine deaminase activity as a diagnostic aid in tuberculous meningitis. South African Medical Journal, 69(4), 505-507.en_ZA
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7963
dc.language.isoen_ZAen_ZA
dc.publisherHealth & Medical Publishing Groupen_ZA
dc.rights.holderSouth African Medical Journalen_ZA
dc.subjectMeninges -- Tuberculosis -- Diagnosisen_ZA
dc.subjectCerebrospinal fluid -- Testingen_ZA
dc.subjectAdenosine deaminase -- Testingen_ZA
dc.titleThe simultaneous determination of cerebrospinal fluid and plasma adenosine deaminase activity as a diagnostic aid in tuberculous meningitisen_ZA
dc.typeArticleen_ZA
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