Predictive value of normal sperm morphology in intrauterine insemination (IUI): A structured literature review

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dc.contributor.authorVan Waart J.
dc.contributor.authorKruger T.F.
dc.contributor.authorLombard C.J.
dc.contributor.authorOmbelet W.
dc.date.accessioned2011-05-15T16:16:36Z
dc.date.available2011-05-15T16:16:36Z
dc.date.issued2001
dc.description.abstractThe aim of the study was to conduct a structured review of the literature published on the use of normal sperm morphology, as an indicator of male fertility potential in intrauterine insemination (IUI) programmes. Published literature in which normal sperm morphology was used to predict pregnancy outcome in IUI during the period 1984-1998 was reviewed. In total, 421 articles were identified via Medline searches. Eighteen provided data that could be tabulated and analysed. Eight of the analysed studies provided sufficient data for statistical analysis, six studies used the Tygerberg 'strict' criteria, and two the WHO guidelines (1987, 1992). A meta-analysis of the six studies in the strict morphology group yielded a risk difference (RD) between the pregnancy rates achieved in the patients below and above the 4% strict criteria threshold of -0.07 (95% CI: -0.11 to -0.03; P < 0.001). The WHO criteria group (1987, 1992) had insufficient data to be analysed. Meta-analysis showed a significant improvement in pregnancy rate above 4% threshold for strict criteria. Accurate evaluation of normal sperm morphology results should be an integral part of evaluating the male factor.
dc.description.versionReview
dc.identifier.citationHuman Reproduction Update
dc.identifier.citation7
dc.identifier.citation5
dc.identifier.issn13554786
dc.identifier.other10.1093/humupd/7.5.495
dc.identifier.urihttp://hdl.handle.net/10019.1/13852
dc.subjectcell structure
dc.subjectclinical protocol
dc.subjectcontrolled study
dc.subjectdata analysis
dc.subjectdiagnostic value
dc.subjectfemale
dc.subjecthealth program
dc.subjecthuman
dc.subjecthuman cell
dc.subjectintrauterine insemination
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmale fertility
dc.subjectmedical assessment
dc.subjectmedical information
dc.subjectmedical literature
dc.subjectmeta analysis
dc.subjectprediction
dc.subjectpregnancy complication
dc.subjectpregnancy rate
dc.subjectpriority journal
dc.subjectpublication
dc.subjectreference value
dc.subjectreview
dc.subjectrisk assessment
dc.subjectsemen analysis
dc.subjectsperm
dc.subjectstatistical analysis
dc.subjectstructure analysis
dc.subjectworld health organization
dc.subjectFemale
dc.subjectGuidelines
dc.subjectHumans
dc.subjectInsemination, Artificial
dc.subjectMale
dc.subjectPredictive Value of Tests
dc.subjectPregnancy
dc.subjectPregnancy Rate
dc.subjectSpermatozoa
dc.subjectWorld Health Organization
dc.titlePredictive value of normal sperm morphology in intrauterine insemination (IUI): A structured literature review
dc.typeReview
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