Incident tuberculosis disease in patients receiving biologic therapies in the Western Cape, South Africa from 2007 to 2018

Du Toit, Tessa; Esterhuizen, Tonya M.; Tiffin, Nicki; Abulfathi, Ahmed A.; Reuter, Helmuth; Decloedt, Eric H.

Incident tuberculosis disease in patients receiving biologic therapies in the Western Cape, South Africa from 2007 to 2018

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dutoit_incident_2019.pdf(681.69 KB)

Date

2019

Authors

Du Toit, Tessa

Esterhuizen, Tonya M.

Publisher

BMC (part of Springer Nature)

Abstract

Background: South Africa has one of the highest tuberculosis incidence rates. Biologic disease-modifying antirheumatic drugs are associated with an increased risk of tuberculosis. The objective of this study was to describe the tuberculosis disease incidence rate among public sector patients receiving biologic therapies in the Western Cape Province. Methods: A retrospective, descriptive analysis was undertaken using routine health data collated by the Provincial Health Data Centre from January 2007 (first use of biologic therapy in the Western Cape) to September 2018. Results: We identified 609 patients treated with tumour necrosis factor-alpha (TNF-α) or non-TNF-α biologic therapies. Thirty-seven (37) patients developed tuberculosis after biologic therapy exposure, of whom the majority (78%) had an immune mediated inflammatory disease and the remainder (22%) a haematologic malignancy. The incidence rate of tuberculosis per 100,000 person-years was 2227 overall [95% confidence interval (CI): 1591, 3037]. Patients treated with TNF-α inhibitors and non-TNF-α inhibitors had estimated incidence rates of 2819 [95% CI: 1669, 4480] and 1825 [95% CI: 1131, 2797], respectively (p = 0.10). Conclusion: Patients exposed to both TNF-α and non-TNF-α biologic therapies may have a higher incidence of tuberculosis disease compared to the background risk of 681 cases per 100,000 per year in the Western Cape.

Description

CITATION: Du Toit, T., 2019. Incident tuberculosis disease in patients receiving biologic therapies in the Western Cape, South Africa from 2007 to 2018. BMC Infectious Diseases, 20:900, doi:10.1186/s12879-020-05624-0.
The original publication is available at https://bmcinfectdis.biomedcentral.com

Keywords

Tuberculosis, Necrosis, Tumors, Biologicals

Citation

Du Toit, T., 2019. Incident tuberculosis disease in patients receiving biologic therapies in the Western Cape, South Africa from 2007 to 2018. BMC Infectious Diseases, 20:900, doi:10.1186/s12879-020-05624-0

URI

http://hdl.handle.net/10019.1/109623

Collections

Research Articles (Clinical Pharmacology)

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