Retinoblastoma outcome at a single institution in South Africa

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dc.contributor.authorKruger, Marianaen_ZA
dc.contributor.authorReynders, Daviden_ZA
dc.contributor.authorOmar, Fareeden_ZA
dc.contributor.authorSchoeman, Judyen_ZA
dc.contributor.authorWedi, Olokoen_ZA
dc.contributor.authorHarvey, Justinen_ZA
dc.date.accessioned2016-01-13T09:48:24Z
dc.date.available2016-01-13T09:48:24Z
dc.date.issued2014-12
dc.descriptionPlease cite as follows: Kruger, M. et al. 2014. Retinoblastoma outcome at a single institution in South Africa. South African Medical Journal, 104(12):859-863, doi:10.7196/SAMJ.8255.en_ZA
dc.descriptionThe original publication is available at http://www.samj.org.zaen_ZA
dc.description.abstractIntroduction. Retinoblastoma (RB) is the most common eye cancer in children. Early detection is necessary for cure. Objective. To compare stage and outcome of children with RB treated at Kalafong Hospital, Pretoria, South Africa (SA), during two time periods (1993 - 2000 and 2001 - 2008, after outreach interventions in 2000 and introduction of compulsory community service for doctors in 1998). Methods. Data collected included demography (age, gender, date of birth), stage and treatment received. The main outcome measure was disease-free survival and the study end-point was 60 months after diagnosis. Results. There were 51 patients during the time period 1993 - 2000 (group 1) and 73 during 2001 - 2008 (group 2), with median ages of 32 and 26 months, respectively (marginally significantly younger in group 2; p=0.046). In group 1, the majority (57%) presented with advanced disease (stages III and IV), a decline in this proportion in group 2 (40%) indicating a downward but not significant trend (p=0.075). Bilateral disease was diagnosed in 22% of patients in group 1 and 33% in group 2. Overall survival was 33% and 43% for groups 1 and 2, respectively. Excluding absconding patients, event-free survival was 50% in group 1, improving to 68% in group 2 (not statistically significant; p=0.18). Fewer patients needed radiotherapy during the second period (statistically significant; p=0.04), probably because of less advanced disease. Conclusion. Poor outcome is probably a result of late diagnosis. It is important to implement a strategy that will ensure early diagnosis and optimal management of RB in SA.en_ZA
dc.description.urihttp://www.samj.org.za/index.php/samj/article/view/8255
dc.description.versionPublisher's versionen_ZA
dc.format.extent5 pagesen_ZA
dc.identifier.citationKruger, M. et al. 2014. Retinoblastoma outcome at a single institution in South Africa. South African Medical Journal, 104(12):859-863, doi:10.7196/SAMJ.8255.en_ZA
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.otherdoi:10.7196/SAMJ.8255
dc.identifier.urihttp://hdl.handle.net/10019.1/98159
dc.language.isoen_ZAen_ZA
dc.publisherHealth & Medical Publishing Groupen_ZA
dc.rights.holderSouth African Medical Journalen_ZA
dc.subjectRetinoblastomaen_ZA
dc.subjectEye cancer in childrenen_ZA
dc.titleRetinoblastoma outcome at a single institution in South Africaen_ZA
dc.typeArticleen_ZA
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