Evidence to support the classification of hyperglycemia first detected in pregnancy to predict diabetes 6–12 weeks postpartum : a single center cohort study

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dc.contributor.authorCoetzee, Ankiaen_ZA
dc.contributor.authorSadhai, Nishendraen_ZA
dc.contributor.authorMason, Deidreen_ZA
dc.contributor.authorHall, David R.en_ZA
dc.contributor.authorConradie, Magdaen_ZA
dc.date.accessioned2022-06-23T13:38:40Zen_ZA
dc.date.available2022-06-23T13:38:40Zen_ZA
dc.date.issued2020-09en_ZA
dc.descriptionCITATION: Coetzee, A. et al. 2020. Evidence to support the classification of hyperglycemia first detected in pregnancy to predict diabetes 6–12 weeks postpartum : a single center cohort study. Diabetes Research and Clinical Practice, 169. doi:10.1016/j.diabres.2020.108421en_ZA
dc.descriptionThe original publication is available at https://www.sciencedirect.com/journal/diabetes-research-and-clinical-practiceen_ZA
dc.description.abstractAims: Diagnostic criteria for type 2 diabetes mellitus (T2DM) applied to women with gestational diabetes mellitus (GDM) may predict postpartum T2DM but requires validation. Methods: Women with GDM aged ≥ 18-years were prospectively evaluated 6–12 weeks after delivery at Tygerberg Hospital, Cape Town, South-Africa (November 2015- December 2018). Glucose status at GDM diagnosis was categorized into i) International Association for Diabetes in Pregnancy Study Group (IADPSG) T2DM (fasting glucose ≥ 7 mmol/L and/or 2hr-glucose ≥ 11.1 mmol/L) or ii) modified National Institute for Care Excellence (NICE) GDM (fasting glucose ≥ 5.6 mmol/L-6.9 mmol/L and/or 2hr-glucose ≥ 7.8 mmol/L-11 mmol/L) and compared with postpartum OGTT. Results: IADPSG T2DM and NICE GDM was present in 35% (n = 64) and 65% (n = 117) of the 181 women who completed the 8 ± 2 weeks postpartum evaluation respectively. Postpartum, the prevalence of T2DM and prediabetes was 26% (n = 47/181) and 15% (n = 28). Antenatal IADPSG T2DM categorization identified 31/47 women with postpartum T2DM (sensitivity 75%; specificity 48%). All of the modified NICE GDM category women who developed T2DM (n = 16/117) had elevations of both fasting and 2hr-glucose values antenatally. Conclusion: The utility of the IADPSG T2DM criteria to predict T2DM postpartum is confirmed. Women with both fasting and 2hr-glucose values above GDM cut-offs emerged as another high-risk category.en_ZA
dc.description.urihttps://www.diabetesresearchclinicalpractice.com/article/S0168-8227(20)30674-4/fulltexten_ZA
dc.description.versionPublishers versionen_ZA
dc.format.extent8 pagesen_ZA
dc.identifier.citationCoetzee, A. et al. 2020. Evidence to support the classification of hyperglycemia first detected in pregnancy to predict diabetes 6–12 weeks postpartum : a single center cohort study. Diabetes Research and Clinical Practice, 169. doi:10.1016/j.diabres.2020.108421en_ZA
dc.identifier.issn0168-8227 (print)en_ZA
dc.identifier.otherdoi:10.1016/j.diabres.2020.108421en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/125404en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherElsevieren_ZA
dc.rights.holderElsevieren_ZA
dc.subjectHyperglycemiaen_ZA
dc.subjectDiabetes in pregnancyen_ZA
dc.subjectPuerperal disordersen_ZA
dc.subjectDiabetesen_ZA
dc.subjectPublic healthen_ZA
dc.titleEvidence to support the classification of hyperglycemia first detected in pregnancy to predict diabetes 6–12 weeks postpartum : a single center cohort studyen_ZA
dc.typeArticleen_ZA
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