Cyclization of enaminones derived from N-phenacylpyrrolidin-2-ones to pyrrolizines under acidic conditions

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dc.contributor.authorMorgans, Garreth L.en_ZA
dc.contributor.authorFernandes, Manuel A.en_ZA
dc.contributor.authorVan Otterlo, Willem A. L.en_ZA
dc.contributor.authorMichael, Joseph P.en_ZA
dc.date.accessioned2022-01-18T13:25:38Z
dc.date.available2022-01-18T13:25:38Z
dc.date.issued2020
dc.descriptionCITATION: Morgans, G. L. et al. 2020. Cyclization of enaminones derived from N-phenacylpyrrolidin-2-ones to pyrrolizines under acidic conditions. Arkivoc, iii:4-23, doi:10.24820/ark.5550190.p011.221.
dc.descriptionThe original publication is available at https://www.arkat-usa.org
dc.description.abstractENGLISH ABSTRACT: Several N-phenacyl enaminones, prepared by Eschenmoser sulfide contraction between Nphenacylpyrrolidine-2-thiones and a range of substituted phenacyl halides, were transformed into 2,3- dihydro-1H-pyrrolizines when treated with acetic acid or silica gel. Yields of the bicyclic products were in the range 57–100% depending on the route followed. Some further reactions of the newly formed pyrrole rings are also reported.en_ZA
dc.description.versionPublisher's version
dc.format.extent20 pagesen_ZA
dc.identifier.citationMorgans, G. L. et al. 2020. Cyclization of enaminones derived from N-phenacylpyrrolidin-2-ones to pyrrolizines under acidic conditions. Arkivoc, iii:4-23, doi:10.24820/ark.5550190.p011.221.
dc.identifier.issn1551-7012 (online)
dc.identifier.otherdoi:10.24820/ark.5550190.p011.221
dc.identifier.urihttp://hdl.handle.net/10019.1/124108
dc.language.isoen_ZAen_ZA
dc.publisherARKAT USAen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectEnaminonesen_ZA
dc.subjectThiolactamsen_ZA
dc.subjectCyclization (Chemistry)en_ZA
dc.subjectPyrrolizidinesen_ZA
dc.titleCyclization of enaminones derived from N-phenacylpyrrolidin-2-ones to pyrrolizines under acidic conditionsen_ZA
dc.typeArticleen_ZA
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