Regional distribution of monoamines and dopamine D1- and D2-receptors in the striatum of the rat

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dc.contributor.authorRussell V.A.
dc.contributor.authorAllin R.
dc.contributor.authorLamm M.C.L.
dc.contributor.authorTaljaard J.J.F.
dc.contributor.authorRussell V.A.
dc.contributor.authorAllin R.
dc.contributor.authorLamm M.C.L.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:17:27Z
dc.date.accessioned2011-05-15T16:17:27Z
dc.date.available2011-05-15T16:17:27Z
dc.date.available2011-05-15T16:17:27Z
dc.date.issued1992
dc.date.issued1992
dc.description.abstractDopamine (DA) D1- and D2-receptor densities were determined in 18 discrete areas of the caudate-putamen-globus pallidus of male Wistar rats and compared to local DA concentrations. All three parameters were found to decrease caudally. The globus pallidus was distinguished by the low concentration of DA and its receptors and high noradrenaline (NA) content. While there were no mediolateral differences in DA or DA D1-receptors, a clear mediolateral gradient was observed for DA D2-receptors which extended over several sections of the brain. The ratio of DA D1- to D2-receptors was significantly higher in the dorsal than in the ventral areas of the mediolateral and caudal striatum. This is the first report of clear dorsoventral differences in parameters relating to DA activity in the striatum. These findings may be of particular significance in understanding the functional dichotomy between the dorsal and ventral striatum.
dc.description.abstractDopamine (DA) D1- and D2-receptor densities were determined in 18 discrete areas of the caudate-putamen-globus pallidus of male Wistar rats and compared to local DA concentrations. All three parameters were found to decrease caudally. The globus pallidus was distinguished by the low concentration of DA and its receptors and high noradrenaline (NA) content. While there were no mediolateral differences in DA or DA D1-receptors, a clear mediolateral gradient was observed for DA D2-receptors which extended over several sections of the brain. The ratio of DA D1- to D2-receptors was significantly higher in the dorsal than in the ventral areas of the mediolateral and caudal striatum. This is the first report of clear dorsoventral differences in parameters relating to DA activity in the striatum. These findings may be of particular significance in understanding the functional dichotomy between the dorsal and ventral striatum.
dc.description.versionArticle
dc.description.versionArticle
dc.identifier.citationNeurochemical Research
dc.identifier.citation17
dc.identifier.citation4
dc.identifier.citationNeurochemical Research
dc.identifier.citation17
dc.identifier.citation4
dc.identifier.issn03643190
dc.identifier.issn03643190
dc.identifier.urihttp://hdl.handle.net/10019.1/14222
dc.identifier.urihttp://hdl.handle.net/10019.1/14222
dc.subjectdopamine; dopamine 1 receptor; dopamine 2 receptor; homovanillic acid; monoamine; noradrenalin; serotonin; animal tissue; article; caudate nucleus; corpus striatum; dopamine brain level; globus pallidus; kinetics; male; nonhuman; noradrenalin brain level; priority journal; putamen; rat; receptor binding; receptor density; Animal; Biogenic Monoamines; Caudate Nucleus; Comparative Study; Corpus Striatum; Globus Pallidus; Male; Putamen; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Support, Non-U.S. Gov't
dc.subjectdopamine
dc.subjectdopamine 1 receptor
dc.subjectdopamine 2 receptor
dc.subjecthomovanillic acid
dc.subjectmonoamine
dc.subjectnoradrenalin
dc.subjectserotonin
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcaudate nucleus
dc.subjectcorpus striatum
dc.subjectdopamine brain level
dc.subjectglobus pallidus
dc.subjectkinetics
dc.subjectmale
dc.subjectnonhuman
dc.subjectnoradrenalin brain level
dc.subjectpriority journal
dc.subjectputamen
dc.subjectrat
dc.subjectreceptor binding
dc.subjectreceptor density
dc.subjectAnimal
dc.subjectBiogenic Monoamines
dc.subjectCaudate Nucleus
dc.subjectComparative Study
dc.subjectCorpus Striatum
dc.subjectGlobus Pallidus
dc.subjectMale
dc.subjectPutamen
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectReceptors, Dopamine
dc.subjectReceptors, Dopamine D1
dc.subjectReceptors, Dopamine D2
dc.subjectSupport, Non-U.S. Gov't
dc.titleRegional distribution of monoamines and dopamine D1- and D2-receptors in the striatum of the rat
dc.titleRegional distribution of monoamines and dopamine D1- and D2-receptors in the striatum of the rat
dc.typeArticle
dc.typeArticle
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